Whole exome sequencing of cell-free DNA – A systematic review and Bayesian individual patient data meta-analysis
Abstract
Molecular profiling of tumor derived cell free DNA (cfDNA) is gaining ground as a prognostic and predictive biomarker. However to what extent cfDNA reflects the full metastatic landscape as currently determined by tumor tissue analysis remains controversial. Though technically challenging, whole exome sequencing (WES) of cfDNA enables thorough evaluation of somatic alterations. Here, we review the feasibility of WES of cfDNA and determine the...
Paper Details
Title
Whole exome sequencing of cell-free DNA – A systematic review and Bayesian individual patient data meta-analysis
Published Date
Feb 1, 2020
Journal
Volume
83
Pages
101951 - 101951
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