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Cancer Treatment Reviews
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Abstract Despite advances in translating conventional research into multi-modal treatment for colorectal cancer (CRC), therapeutic resistance and relapse remain unresolved in advanced resectable and, particularly, non-resectable disease. Genome and transcriptome sequencing and editing technologies, coupled with interaction mapping and machine learning, are transforming biomedical research, representing the most rational hope to overcome unmet research and clinical challenges. Rapid progress in b...
#1Emilie Le Rhun (UZH: University of Zurich)
#2Matthias Preusser (Medical University of Vienna)H-Index: 45
Last.Michael Weller (UZH: University of Zurich)H-Index: 105
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Abstract Glioblastomas are intrinsic brain tumors thought to originate from neuroglial stem or progenitor cells. More than 90% of glioblastomas are isocitrate dehydrogenase (IDH)-wildtype tumors. Incidence increases with age, males are more often affected. Beyond rare instances of genetic predisposition and irradiation exposure, there are no known glioblastoma risk factors. Surgery as safely feasible followed by involved-field radiotherapy plus concomitant and maintenance temozolomide chemothera...
Abstract Background Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers worldwide. Recent studies have shown that 4-20% of patients with PDAC have a germline BReast CAncer (gBRCA) genes 1 and 2 mutation (m). Because homologous recombination is impaired in patients with gBRCAm, some reports suggested that these patients may be more sensitive to platinum compounds. Therefore, this systematic review and meta-analysis focused on benefit of patients with gBRCAm receiving a plati...
#1Daniel H. Schanne (UZH: University of Zurich)
#2Jana Heitmann (UZH: University of Zurich)H-Index: 1
Last.Nicolaus Andratschke (UZH: University of Zurich)H-Index: 23
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Abstract Background The concept of oligometastatic disease (OMD) has expanded the scope of potentially curative therapy for metastatic NSCLC. However, large uncertainties remain regarding its definition and optimal management strategies. We therefore conducted a systematic review to investigate the value of various multimodality treatment concepts. Methods We searched the available literature in Pubmed, Medline and EMBASE using the terms “oligomet*”, “synchron*”, “oligorec*”, “metachr*” “NSCLC”,...
Abstract Collecting ducts carcinoma (CDC) is a rare and aggressive histological subtype of renal cancer accounting for only 1% of renal tumors. Usually patients present in bad clinical conditions due to a symptomatic disease with synchronous metastasis. Due to the rarity of CDC, data from prospective trials evaluating the best treatment for these patients are limited. The prognosis is poor with a median overall survival of around 11 months for patients with metastatic disease. The best treatment...
#1Flora Zagouri (Alexandra Hospital)H-Index: 23
#2Anna-Maria Korakiti (Alexandra Hospital)
Last.M.A. Dimopoulos (Alexandra Hospital)H-Index: 103
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Abstract Background Cervical cancer is one of the most common malignancies diagnosed during pregnancy. Taxanes administration has been established as theurapetic regimen in non pregrant women. Objectives This systemic review and meta-analysis aims to synthesize all available data from cervical cancer series in pregnant women and evaluate the efficacy and safety of taxanes during pregnancy. Search Strategy Eligible articles were identified by a search of ClinicalTrial.gov and MEDLINE databases fo...
#1Francesco GelsominoH-Index: 12
#2Giuseppe LambertiH-Index: 2
Last.Andrea ArdizzoniH-Index: 45
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Abstract Small cell lung cancer (SCLC) was defined as a “recalcitrant cancer” because of its dismal prognosis and lack of outcome improvements in the last 30 years. Immunotherapy with checkpoint inhibitors revolutionized treatment in many cancer types and results from the IMpower133 study, a double-blind placebo-controlled phase III trial, showed overall-survival benefit for atezolizumab when added to standard platinum-etoposide chemotherapy in first-line SCLC setting for the first time since ye...
#1Anne W.M. Lee (HKU: University of Hong Kong)H-Index: 30
#2Wai Tong Ng (Pamela Youde Nethersole Eastern Hospital)H-Index: 20
Last.Primož StrojanH-Index: 23
view all 10 authors...
Abstract As a consequence of the current excellent loco-regional control rates attained using the generally accepted treatment paradigms involving intensity-modulated radiotherapy for nasopharyngeal carcinoma (NPC), only 10-20% of patients will suffer from local and/or nodal recurrence after primary treatment. Early detection of recurrence is important as localized recurrent disease is still potentially salvageable, but this treatment often incurs a high risk of major toxicities. Due to the poss...
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