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Cancer Treatment Reviews
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Last. Evandro de Azambuja (ULB: Université libre de Bruxelles)H-Index: 44
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Abstract HER2-positive breast cancer is an aggressive subtype identified in the 1980s. The development of therapies targeting the HER2 has improved outcomes. The current standard of care, established in 2012 is dual blockade with trastuzumab + pertuzumab as first-line followed by TDM1 as second-line. Several suboptimal choices are available in third line or more. In 2019 the presentation of several trials evaluating new drugs and regimens in third-line has re-opened questions about sequencing, t...
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The severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) and its clinical manifestation, the coronavirus disease 2019 (COVID19) have rapidly spread across the globe, leading to the declaration of a pandemic While most present mild symptoms, it appears as though nearly 20% of confirmed patients develop significant complications These include acute respiratory distress syndrome, septic shock and multi-organ failure, with a 3-6% mortality A plethora of treatments has been or is being assesse...
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#1Elisa Fontana (Sarah Cannon Research Institute)
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The COVID-19 pandemic affected many activities in the healthcare system including oncology drug development Clinical trial recruitment was temporary halted in many centres to reduce patients and healthcare workers� potential exposure to the virus Conversely, to continue offering treatments for patients already on effective therapies, multiple actions were timely put in place, resulting in simplification of trial-related procedures for patients and clinicians� best interest, reduction of the oper...
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Abstract Autophagy is a self-degradative cellular process, involved in stress response such as starvation, hypoxia, and oxidative stress. This mechanism balances macro-molecule recycling to regulate cell homeostasis. In cancer, autophagy play a role in the development and progression, while several studies describe it as one of the key processes in drug resistance. In the last years, in addition to standard anti-cancer treatments such as chemotherapies and irradiation, targeted therapy became on...
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#1Maria Vittoria Dieci (UNIPD: University of Padua)H-Index: 22
#2Federica Miglietta (UNIPD: University of Padua)H-Index: 6
Last. Valentina Guarneri (UNIPD: University of Padua)H-Index: 33
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Abstract The overexpression of human epidermal growth factor receptor-2 (HER2) results in a biologically and clinically aggressive breast cancer (BC) subtype. Since the introduction of anti-HER2 targeted agents, survival rates of patients with HER2-positive metastatic BC have dramatically improved. Currently, although the treatment decision process in metastatic BC is primarily based on HER2 and hormone-receptor (HR) status, a rapidly growing body of data suggests that several other sources of b...
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#1Mohammed Abdul-Latif (Middlesex University)
#2Katherine Townsend (The Royal Marsden NHS Foundation Trust)
Last. Khurum Khan (UCL: University College London)H-Index: 1
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Abstract Gastrointestinal cancers include colorectal, gastric, oesophageal, pancreatic and liver cancers. They continue to be a significant cause of mortality and morbidity worldwide. Current treatment strategies include chemotherapy, surgery, radiotherapy and targeted therapies. Immunotherapy has recently been incorporated in treatment regimens for some gastrointestinal malignancies and research into different immune modifying treatments is being carried out in this context. Approaches to immun...
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#1Ralf Gutzmer (MHH: Hannover Medical School)H-Index: 51
#2Dirk Vordermark (MLU: Martin Luther University of Halle-Wittenberg)H-Index: 33
Last. Christoph HöllerH-Index: 7
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Abstract Melanoma brain metastases (MBM) are common and associated with a particularly poor prognosis; they directly cause death in 60-70% of melanoma patients. In the past, systemic treatments have shown response rates around 5%, whole brain radiation as standard of care has achieved a median overall survival of approximately three months. Recently, the combination of immune checkpoint inhibitors and combinations of MAP-kinase inhibitors both have shown very promising response rates of up to 55...
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Abstract Molecular profiling provides the insight that specific genetic alterations can be detected across a wide range of different histologically characterised tumour types. Thus, the basic concept of basket trials (BTs) to target those genetic alterations with the same anti-tumour agents independent of the underlying tumour type was tumour agnostic. BTs can be divided into tumour gnostic, tumour semi-gnostic, and tumour agnostic trials which cover BTs of the conventional and the complex multi...
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#2Timothy JacobsH-Index: 1
Last. Eitan Amir (U of T: University of Toronto)H-Index: 37
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#1Maike Uijen (Radboud University Nijmegen)H-Index: 1
#2Gerben Lassche (Radboud University Nijmegen)H-Index: 2
Last. C.M.L. van Herpen (Radboud University Nijmegen)H-Index: 21
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Abstract Background Salivary duct carcinoma (SDC) is an aggressive subtype of salivary gland cancer. Approximately half of SDC patients will develop recurrences or metastases. Therapeutic palliative therapy is therefore often needed. The majority of SDC tumors expresses the androgen receptor (AR) and one-third expresses human epidermal growth factor receptor 2 (HER2), both are potential therapeutic targets. The aim of this paper is to systematically review and summarize the evidence on systemic ...
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