Parkinson’s disease recovery by GM1 oligosaccharide treatment in the B4galnt1+/− mouse model
Abstract
Given the recent in vitro discovery that the free soluble oligosaccharide of GM1 is the bioactive portion of GM1 for neurotrophic functions, we investigated its therapeutic potential in the B4galnt1 +/− mice, a model of sporadic Parkinson’s disease. We found that the GM1 oligosaccharide, systemically administered, reaches the brain and completely rescues the physical symptoms, reduces the abnormal nigral α-synuclein content, restores nigral...
Paper Details
Title
Parkinson’s disease recovery by GM1 oligosaccharide treatment in the B4galnt1+/− mouse model
Published Date
Dec 18, 2019
Journal
Volume
9
Issue
1
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