Core Binding Factor Leukemia: Chromatin Remodeling Moves Towards Oncogenic Transcription
Abstract
Acute myeloid leukemia (AML), the most common acute leukemia in adults, is a heterogeneous malignant clonal disorder arising from multipotent hematopoietic progenitor cells characterized by genetic and concerted epigenetic aberrations. Core binding factor-Leukemia (CBFL) is characterized by the recurrent reciprocal translocations t(8;21)(q22;q22) or inv(16)(p13;q22) that, expressing the distinctive RUNX1-RUNX1T1 (also known as Acute myeloid...
Paper Details
Title
Core Binding Factor Leukemia: Chromatin Remodeling Moves Towards Oncogenic Transcription
Published Date
Dec 7, 2019
Journal
Volume
11
Issue
12
Pages
1973 - 1973
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