Original paper
Targeting specificity of APOBEC-based cytosine base editor in human iPSCs determined by whole genome sequencing
Abstract
DNA base editors have enabled genome editing without generating DNA double strand breaks. The applications of this technology have been reported in a variety of animal and plant systems, however, their editing specificity in human stem cells has not been studied by unbiased genome-wide analysis. Here we investigate the fidelity of cytidine deaminase-mediated base editing in human induced pluripotent stem cells (iPSCs) by whole genome sequencing...
Paper Details
Title
Targeting specificity of APOBEC-based cytosine base editor in human iPSCs determined by whole genome sequencing
Published Date
Nov 25, 2019
Journal
Volume
10
Issue
1
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Notes
History