Comparison of Genetic Liability for Sleep Traits Among Individuals With Bipolar Disorder I or II and Control Participants

Importance

Insomnia, hypersomnia, and an evening chronotype are common in individuals with bipolar disorder (BD), but whether this reflects shared genetic liability is unclear. Stratifying by BD subtypes could elucidate this association and inform sleep and BD research.

Objective

To assess whether polygenic risk scores (PRSs) for sleep traits are associated with BD subtypes I and II.

Design, Setting, and Participants

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