DNA methylation aging clocks: challenges and recommendations
Abstract
Epigenetic clocks comprise a set of CpG sites whose DNA methylation levels measure subject age. These clocks are acknowledged as a highly accurate molecular correlate of chronological age in humans and other vertebrates. Also, extensive research is aimed at their potential to quantify biological aging rates and test longevity or rejuvenating interventions. Here, we discuss key challenges to understand clock mechanisms and biomarker utility. This...
Paper Details
Title
DNA methylation aging clocks: challenges and recommendations
Published Date
Nov 25, 2019
Journal
Volume
20
Issue
1
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