Branding/Logomark minus arrow-point-to-down Citation Combined Shape Icon/Bookmark-empty Icon/Copy Icon/Collection Icon/Close Copy 7 Icon/List no author result Created with Sketch.
Loading Scinapse...
IF
13.21
Papers
5773
Papers 5756
1 page of 576 pages (5,756 results)
Newest
2018 in Genome BiologyIF: 13.21
Michael D. Morgan6
Estimated H-index: 6
(Wellcome Trust Sanger Institute),
John C. Marioni44
Estimated H-index: 44
(University of Cambridge)
Population phenotypic variation can arise from genetic differences between individuals, or from cellular heterogeneity in an isogenic group of cells or organisms. The emergence of gene expression differences between genetically identical cells is referred to as gene expression noise, the sources of which are not well understood. In this work, by studying gene expression noise between multiple cell lineages and mammalian species, we find consistent evidence of a role for CpG islands as sources of...
1 Citations Source Cite
2018 in Genome BiologyIF: 13.21
Timothy Daley1
Estimated H-index: 1
(Stanford University),
Zhixiang Lin3
Estimated H-index: 3
(Stanford University)
+ 3 AuthorsLei S. Qi28
Estimated H-index: 28
(Stanford University)
Pooled CRISPR screens allow researchers to interrogate genetic causes of complex phenotypes at the genome-wide scale and promise higher specificity and sensitivity compared to competing technologies. Unfortunately, two problems exist, particularly for CRISPRi/a screens: variability in guide efficiency and large rare off-target effects. We present a method, CRISPhieRmix, that resolves these issues by using a hierarchical mixture model with a broad-tailed null distribution. We show that CRISPhieRm...
Source Cite
2018 in Genome BiologyIF: 13.21
Chunhui Ma1
Estimated H-index: 1
(Peking Union Medical College),
Mengqi Chang1
Estimated H-index: 1
(Peking Union Medical College)
+ 14 AuthorsDi Wang1
Estimated H-index: 1
(Peking Union Medical College)
Background N6-methyladenosine (m6A) is an important epitranscriptomic mark with high abundance in the brain. Recently, it has been found to be involved in the regulation of memory formation and mammalian cortical neurogenesis. However, while it is now established that m6A methylation occurs in a spatially restricted manner, its functions in specific brain regions still await elucidation.
1 Citations Source Cite
2018 in Genome BiologyIF: 13.21
Yu Hong1
Estimated H-index: 1
(Peking University),
Guangqing Lu2
Estimated H-index: 2
(Peking Union Medical College)
+ 2 AuthorsYu Zhang40
Estimated H-index: 40
(Peking University)
CRISPR/dCas9 binds precisely to defined genomic sequences through targeting of guide RNA (gRNA) sequences. In vivo imaging of genomic loci can be achieved by recruiting fluorescent proteins using either dCas9 or gRNA. We thoroughly validate and compare the effectiveness and specificity of several dCas9/gRNA genome labeling systems. Surprisingly, we discover that in the gRNA-labeling strategies, accumulation of tagged gRNA transcripts leads to non-specific labeling foci. Furthermore, we develop n...
2 Citations Source Cite
2018 in Genome BiologyIF: 13.21
François Mallard1
Estimated H-index: 1
,
Viola Nolte21
Estimated H-index: 21
+ 2 AuthorsChristian Schlötterer38
Estimated H-index: 38
Population genetic theory predicts that rapid adaptation is largely driven by complex traits encoded by many loci of small effect. Because large-effect loci are quickly fixed in natural populations, they should not contribute much to rapid adaptation. To investigate the genetic architecture of thermal adaptation — a highly complex trait — we performed experimental evolution on a natural Drosophila simulans population. Transcriptome and respiration measurements reveal extensive metabolic rewiring...
Download PDF Cite
2018 in Genome BiologyIF: 13.21
Gaetan Burgio14
Estimated H-index: 14
(Australian National University)
In the recent Research Highlight [1], it has been highlighted that part b of Fig. 1 was incorrectly labelled as “sgRNA + tracrRNA” instead of “sgRNA (crRNA + tracrRNA)”. An updated Figure 1, including also the amended figure legend has therefore been provided below.
Source Cite
2018 in Genome BiologyIF: 13.21
Martha Rendón-Anaya (Swedish University of Agricultural Sciences), Alfredo Herrera-Estrella42
Estimated H-index: 42
(CINVESTAV)
A recent study identifies a locus controlling seed dormancy – a key trait of the ‘domestication syndrome’ – that has been selected for in parallel across multiple crop families.
Source Cite
2018 in Genome BiologyIF: 13.21
Cong Ma1
Estimated H-index: 1
,
Mingfu Shao6
Estimated H-index: 6
,
Carl Kingsford21
Estimated H-index: 21
Transcripts are frequently modified by structural variations, which lead to fused transcripts of either multiple genes, known as a fusion gene, or a gene and a previously non-transcribed sequence. Detecting these modifications, called transcriptomic structural variations (TSVs), especially in cancer tumor sequencing, is an important and challenging computational problem. We introduce SQUID, a novel algorithm to predict both fusion-gene and non-fusion-gene TSVs accurately from RNA-seq alignments....
1 Citations Download PDF Cite
2018 in Genome BiologyIF: 13.21
Yuchao Jiang5
Estimated H-index: 5
(University of North Carolina at Chapel Hill),
Rujin Wang1
Estimated H-index: 1
(University of North Carolina at Chapel Hill)
+ 3 AuthorsNancy R. Zhang23
Estimated H-index: 23
(University of Pennsylvania)
High-throughput DNA sequencing enables detection of copy number variations (CNVs) on the genome-wide scale with finer resolution compared to array-based methods but suffers from biases and artifacts that lead to false discoveries and low sensitivity. We describe CODEX2, as a statistical framework for full-spectrum CNV profiling that is sensitive for variants with both common and rare population frequencies and that is applicable to study designs with and without negative control samples. We demo...
1 Citations Download PDF Cite
2018 in Genome BiologyIF: 13.21
Eugenia D’Atanasio6
Estimated H-index: 6
,
Beniamino Trombetta11
Estimated H-index: 11
+ 14 AuthorsElizabeth Watson4
Estimated H-index: 4
(Swedish Museum of Natural History)
Little is known about the peopling of the Sahara during the Holocene climatic optimum, when the desert was replaced by a fertile environment. In order to investigate the role of the last Green Sahara in the peopling of Africa, we deep-sequence the whole non-repetitive portion of the Y chromosome in 104 males selected as representative of haplogroups which are currently found to the north and to the south of the Sahara. We identify 5,966 mutations, from which we extract 142 informative markers th...
4 Citations Source Cite
12345678910