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Genome Biology
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13.21
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Papers 5840
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Published on Dec 1, 2019in Genome Biology 13.21
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Published on Jan 25, 2019in Genome Biology 13.21
Jean-Philippe Fortin9
Estimated H-index: 9
(Genentech),
Jenille Tan5
Estimated H-index: 5
(Genentech)
+ 4 AuthorsScott E. Martin4
Estimated H-index: 4
(Genentech)
Background Genome-wide loss-of-function screens using the CRISPR/Cas9 system allow the efficient discovery of cancer cell vulnerabilities. While several studies have focused on correcting for DNA cleavage toxicity biases associated with copy number alterations, the effects of sgRNAs co-targeting multiple genomic loci in CRISPR screens have not been discussed.
4 Citations Source Cite
Published on Apr 26, 2019in Genome Biology 13.21
Wei-Cheng Liang7
Estimated H-index: 7
,
Cheuk-Wa Wong3
Estimated H-index: 3
+ 8 AuthorsWei-ming Fu13
Estimated H-index: 13
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Published on Feb 13, 2019in Genome Biology 13.21
Domenico Alessandro Silvestris1
Estimated H-index: 1
,
Ernesto Picardi22
Estimated H-index: 22
(University of Bari)
+ 7 AuthorsAngela Gallo20
Estimated H-index: 20
Background Adenosine-to-inosine (A-to-I) RNA editing is an essential post-transcriptional mechanism mediated by ADAR enzymes that have been recently associated with cancer.
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Published on Mar 27, 2019in Genome Biology 13.21
Benjamin E. Mead5
Estimated H-index: 5
,
Jeffrey M. Karp47
Estimated H-index: 47
1 Citations Source Cite
Published on Jan 22, 2019in Genome Biology 13.21
Barbara Cheifet1
Estimated H-index: 1
(BioMed Central)
We polled the Editorial Board of Genome Biology to ask where they see genomics going in the next few years. Here are some of their responses.
1 Citations Source Cite
Published on Apr 29, 2019in Genome Biology 13.21
Daryl M. Gohl13
Estimated H-index: 13
(University of Minnesota),
Alessandro Magli10
Estimated H-index: 10
(University of Minnesota)
+ 8 AuthorsShana L. McDevitt (University of California)
Quantification of DNA sequence tags from engineered constructs such as plasmids, transposons, or other transgenes underlies many functional genomics measurements. Typically, such measurements rely on PCR followed by next-generation sequencing. However, PCR amplification can introduce significant quantitative error. We describe REcount, a novel PCR-free direct counting method. Comparing measurements of defined plasmid pools to droplet digital PCR data demonstrates that REcount is highly accurate ...
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Published on Apr 5, 2019in Genome Biology 13.21
Alexa B. R. McIntyre7
Estimated H-index: 7
(Cornell University),
Rachid Ounit7
Estimated H-index: 7
(University of California)
+ 17 AuthorsSofia Ahsanuddin5
Estimated H-index: 5
(Cornell University)
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Published on Mar 21, 2019in Genome Biology 13.21
Chantriolnt Andreas Kapourani1
Estimated H-index: 1
,
Guido Sanguinetti32
Estimated H-index: 32
Measurements of single-cell methylation are revolutionizing our understanding of epigenetic control of gene expression, yet the intrinsic data sparsity limits the scope for quantitative analysis of such data. Here, we introduce Melissa (MEthyLation Inference for Single cell Analysis), a Bayesian hierarchical method to cluster cells based on local methylation patterns, discovering patterns of epigenetic variability between cells. The clustering also acts as an effective regularization for data im...
1 Citations Source Cite
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