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Christopher G. Bell
University of Southampton
EpigenomicsDNA methylationEpigeneticsGeneticsBiology
69Publications
23H-index
2,789Citations
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Publications 76
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#1Emily H Bowler (University of Southampton)H-Index: 2
#2Alex Smith-Vidal (University of Southampton)
Last. Rob M. Ewing (University of Southampton)H-Index: 22
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ABSTRACTDNA methyltransferase I plays the central role in maintenance of CpG DNA methylation patterns across the genome and alteration of CpG methylation patterns is a frequent and significant occu...
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#1Richard J. Acton (University of Southampton)H-Index: 1
#2Wei Yuan ('KCL': King's College London)H-Index: 10
Last. Christopher G. Bell (QMUL: Queen Mary University of London)H-Index: 23
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Understanding how the epigenome deteriorates with age and subsequently impacts on biological function may bring unique insights to ageing-related disease mechanisms. As a central cellular apparatus, tRNAs are fundamental to the information flow from DNA to proteins. Whilst only being transcribed from ~46kb (
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#1Christopher G. Bell (QMUL: Queen Mary University of London)H-Index: 23
#2Robert Lowe (QMUL: Queen Mary University of London)H-Index: 17
Last. Vardhman K. Rakyan (QMUL: Queen Mary University of London)H-Index: 34
view all 21 authors...
Epigenetic clocks comprise a set of CpG sites whose DNA methylation levels measure subject age. These clocks are acknowledged as a highly accurate molecular correlate of chronological age in humans and other vertebrates. Also, extensive research is aimed at their potential to quantify biological aging rates and test longevity or rejuvenating interventions. Here, we discuss key challenges to understand clock mechanisms and biomarker utility. This requires dissecting the drivers and regulators of ...
12 CitationsSource
#1Emily H Bowler (University of Southampton)H-Index: 2
#2Alex Smith-Vidal (University of Southampton)
Last. Rob M. Ewing (University of Southampton)H-Index: 22
view all 10 authors...
Background: DNA methyltransferase I is the primary eukaryotic DNA methyltransferase engaged in maintenance of CpG DNA methylation patterns across the genome. Alteration of CpG methylation patterns and levels is a frequent and significant occurrence across many cancers, and targeted inhibition of Dnmt1 has become an approach of choice for select malignancies. There has been significant interest both in the methyltransferase activity as well as methylation-independent functions of Dnmt1. A previou...
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We have previously demonstrated inverse associations between maternal 25(OH)-vitamin D status and perinatal DNA methylation at the retinoid-X-receptor-alpha (RXRA) locus and between RXRA methylation and offspring bone mass. We therefore used an existing randomised trial to test the hypothesis that maternal gestational vitamin D supplementation would lead to reduced perinatal RXRA locus DNA methylation. The Maternal Vitamin D Osteoporosis Study (MAVIDOS) was a multicentre, double-blind, randomise...
5 CitationsSource
#1Elizabeth M. Curtis (University of Southampton)H-Index: 9
#2Philip Titcombe (University of Southampton)H-Index: 3
Last. Curtis Cooper (University of Oxford)H-Index: 174
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#1Matthias Thurner (University of Oxford)H-Index: 4
#2Martijn van de Bunt (University of Oxford)H-Index: 24
Last. Mark I. McCarthy (University of Oxford)H-Index: 162
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Human genetic studies have emphasised the dominant contribution of pancreatic islet dysfunction to development of Type 2 Diabetes (T2D). However, limited annotation of the islet epigenome has constrained efforts to define the molecular mechanisms mediating the, largely regulatory, signals revealed by Genome-Wide Association Studies (GWAS). We characterised patterns of chromatin accessibility (ATAC-seq, n=17) and DNA methylation (whole-genome bisulphite sequencing, n=10) in human islets, generati...
38 CitationsSource
#1Matthias Thurner (University of Oxford)H-Index: 4
#2Martijn van de Bunt (University of Oxford)H-Index: 24
Last. Mark I. McCarthy (University of Oxford)H-Index: 162
view all 15 authors...
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#1Christopher G. BellH-Index: 23
#2Fei GaoH-Index: 13
Last. Tim D. Spector ('KCL': King's College London)H-Index: 165
view all 12 authors...
Integrating epigenetic data with genome-wide association study (GWAS) results can reveal disease mechanisms. The genome sequence itself also shapes the epigenome, with CpG density and transcription factor binding sites (TFBSs) strongly encoding the DNA methylome.Therefore, genetic polymorphism impacts on the observed epigenome. Furthermore, large genetic variants alter epigenetic signal dosage. Here, we identify DNA methylation variability between GWAS-SNP risk and non-risk haplotypes. In three ...
22 CitationsSource
#1C Simner (University of Southampton)H-Index: 2
#2Boris Novakovic (Royal Children's Hospital)H-Index: 23
Last. Jane K. Cleal (University of Southampton)H-Index: 18
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Abstract Introduction Placental transfer of amino acids via amino acid transporters is essential for fetal growth. Little is known about the epigenetic regulation of amino acid transporters in placenta. This study investigates the DNA methylation status of amino acid transporters and their expression across gestation in human placenta. Methods BeWo cells were treated with 5-aza-2′-deoxycytidine to inhibit methylation and assess the effects on amino acid transporter gene expression. The DNA methy...
5 CitationsSource
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