Label-free multiphoton imaging of β-amyloid plaques in Alzheimer’s disease mouse models

β -Amyloid ( Aβ ) plaque, representing the progressive accumulation of the protein that mainly consists of Aβ , is one of the prominent pathological hallmarks of Alzheimer's disease (AD). Label-free imaging of Aβ plaques holds the potential to be a histological examination tool for diagnosing AD. We applied label-free multiphoton microscopy to identify extracellular Aβ plaque as well as intracellular Aβ accumulation for the first time from AD...