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Lidian Chen
Fujian University of Traditional Chinese Medicine
Randomized controlled trialPhysical therapyApoptosisStrokeMedicine
137Publications
22H-index
1,891Citations
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Publications 118
Newest
#1Li LiH-Index: 1
#2Jia HuangH-Index: 15
Last. Lidian ChenH-Index: 22
view all 11 authors...
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#1Weilin Liu (University of Oklahoma Health Sciences Center)
#2Huawei Lin (FJUTCM: Fujian University of Traditional Chinese Medicine)
Last. Lidian Chen (FJUTCM: Fujian University of Traditional Chinese Medicine)H-Index: 22
view all 9 authors...
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder with clinical, biological, and pathological features occurring along a continuum from normal to end-stage disease. Currently, the diagnosis of AD depends on clinical assessments and post-mortem neuropathology, which is unbenefited early diagnosis and progressive monitoring. In recent years, clinical studies have reported that the level of cerebrospinal fluid (CSF) and blood neurogranin (Ng) are closely related to the occurrence...
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#1Rui Xia (FJUTCM: Fujian University of Traditional Chinese Medicine)H-Index: 4
#2Mingyue Wan (FJUTCM: Fujian University of Traditional Chinese Medicine)
Last. Guohua Zheng (University of Medicine and Health Sciences)H-Index: 3
view all 10 authors...
Introduction Cognitive frailty (CF) is a clinical manifestation characterised by the simultaneous presence of both physical frailty and cognitive impairment among older adults without dementia and has become a new target for healthy ageing. Increasing evidence shows that regular Baduanjin (a traditional Chinese mind–body exercise) training is beneficial in improving physical function and cognitive ability in the older adults. The primary aim of this trial is to observe the effect of Baduanjin on...
Source
#1Zhifu Wang (FJUTCM: Fujian University of Traditional Chinese Medicine)H-Index: 2
#2Bingbing Lin (FJUTCM: Fujian University of Traditional Chinese Medicine)H-Index: 3
Last. Jing Tao (FJUTCM: Fujian University of Traditional Chinese Medicine)H-Index: 20
view all 9 authors...
Hippocampal 5-HT1A receptors and the PKA signaling pathway have been implicated in learning and memory. This study aimed to investigate whether PKA signaling mediated by 5-HT1A receptors was involved in the electroacupuncture (EA)-mediated learning and memory in a rat model of middle cerebral artery occlusion-induced cognitive deficit (MICD). Compared to no treatment or non-acupoint EA treatment, EA at DU20 and DU24 acupoints improved the neurological deficit of scores, shortened escape latency ...
Source
#1Ruizhu Lin (FJUTCM: Fujian University of Traditional Chinese Medicine)
#2Jia Huang (FJUTCM: Fujian University of Traditional Chinese Medicine)H-Index: 15
Last. Lidian Chen (FJUTCM: Fujian University of Traditional Chinese Medicine)H-Index: 22
view all 10 authors...
Vascular cognitive impairment no dementia (VCIND) is likely to develop into vascular dementia (VD) without intervention. The clinical efficacy of electroacupuncture (EA) for VCIND has been previously demonstrated. However, the neuroimaging mechanism of EA for VCIND has not been elucidated clearly. This trial is designed to provide solid evidence for the efficacy and neuroimaging mechanism of EA treatment for patients with VCIND. This ongoing study is an assessor-blind, parallel-group, randomized...
Source
#1Shengxiang Liang (FJUTCM: Fujian University of Traditional Chinese Medicine)
#2Jiayong Zhang (FJUTCM: Fujian University of Traditional Chinese Medicine)
Last. Lidian Chen (FJUTCM: Fujian University of Traditional Chinese Medicine)H-Index: 22
view all 13 authors...
Abstract Brain ischemia leads to insufficient oxygen supply or hypoxia and thus to ischemic stroke or chronic hypoperfusion, which results in neuronal death and white matter damage is irreversible or partially recoverable under the interruption of blood flow more than a few minutes. The present study investigated the abnormal characteristics of white matter integrity after the chronic cerebral ischemia in a mouse model of bilateral carotid artery stenosis and the acute cerebral ischemia in a mou...
Source
#1Shu Wang (FZU: Fuzhou University)
#2Bingbing Lin (FJUTCM: Fujian University of Traditional Chinese Medicine)H-Index: 3
Last. Jianxin Chen (Fujian Normal University)H-Index: 21
view all 13 authors...
Stroke is a significant cause of morbidity and long-term disability globally. Detection of injured neuron is a prerequisite for defining the degree of focal ischemic brain injury, which can be used to guide further therapy. Here, we demonstrate the capability of two-photon microscopy (TPM) to label-freely identify injured neurons on unstained thin section and fresh tissue of rat cerebral ischemia-reperfusion model, revealing definite diagnostic features compared with conventional staining images...
Source
#1Zhi-Feng Zhong (Fujian Medical University)H-Index: 1
#2Jing HanH-Index: 3
Last. Lidian Chen (FJUTCM: Fujian University of Traditional Chinese Medicine)H-Index: 22
view all 8 authors...
Salidroside, a phenylpropanoid glycoside, is a main bioactive component of Rhodiola rosea L. Previous studies have indicated that salidroside has prominent anti-stroke effects in cerebral ischemia/reperfusion models. But the underline mechanisms involved are not well understood. This study was designed to illustrate the anti-stroke effects of salidroside on MCAO-induced models in rats and its potential mechanisms on dopaminergic system. We discovered that administration with salidroside increase...
Source
#1Shu Wang (FZU: Fuzhou University)
#2Bingbing Lin (FJUTCM: Fujian University of Traditional Chinese Medicine)H-Index: 3
Last. Jianxin Chen (Fujian Normal University)H-Index: 21
view all 11 authors...
Source
#1Nichol M.L. Wong (HKU: University of Hong Kong)H-Index: 5
#2Robin Shao (HKU: University of Hong Kong)H-Index: 4
Last. Tatia M.C. Lee (HKU: University of Hong Kong)H-Index: 43
view all 6 authors...
Chronic loneliness predicts mood disturbances and onset of major depressive disorder. However, little research has examined the neural correlates of individual difference in susceptibility to perceiving loneliness. In addition, the role of cerebellum, which is heavily implicated in social, cognitive and affective processes, in loneliness is unclear. We studied 99 healthy individuals divided into susceptible, concordant and robust groups depending on whether the participant’s loneliness level was...
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