Distinct Molecular Phenotype of Sporadic Colorectal Cancers Among Young Patients Based on Multiomics Analysis

Little is known about etiologies underlying the steadily increasing incidence of young-onset colorectal cancer (CRC) (at age <50 years). Five of 6 patients with young-onset CRC do not have microsatellite instable–positive tumors, nor do they carry germline mutations associated with cancer predisposition. Young patients also experience more aggressive disease relative to older patients. Together, these patterns are consistent with a unique...