Production of ACE inhibitory peptides from corn germ meal by an enzymatic membrane reactor with a novel gradient diafiltration feeding working-mode and in vivo evaluation of antihypertensive effect

This study investigated the performance of an enzymatic membrane reactor (EMR) with a new gradient diafiltration feeding (GDF) working-mode on the production of peptide with potent angiotensin-converting enzyme (ACE) inhibitory activity from corn germ meal (CGM) under the selected conditions. The antihypertensive effect of the released peptide was evaluated in vivo. Results showed that the protein conversion rate and the peptide yield were...