Epigenetic remodelling licences adult cholangiocytes for organoid formation and liver regeneration
Abstract
Following severe or chronic liver injury, adult ductal cells (cholangiocytes) contribute to regeneration by restoring both hepatocytes and cholangiocytes. We recently showed that ductal cells clonally expand as self-renewing liver organoids that retain their differentiation capacity into both hepatocytes and ductal cells. However, the molecular mechanisms by which adult ductal-committed cells acquire cellular plasticity, initiate organoids and...
Paper Details
Title
Epigenetic remodelling licences adult cholangiocytes for organoid formation and liver regeneration
Published Date
Nov 1, 2019
Journal
Volume
21
Issue
11
Pages
1321 - 1333
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History