Increased striatal dopamine in carriers of GBA mutations: compensation or epiphenomenon?

LRRK2 and GBA mutations are common causes of genetic Parkinson's disease. Studies in non-manifesting carriers of these mutations provide the opportunity to investigate prodromal changes that could be relevant for understanding the pathophysiology of Parkinson's disease. Longitudinal studies in patients with rapid eye movement (REM) sleep behaviour disorder, at high risk for Parkinson's disease and other α-synucleinopathies, reveal an evolution...