Glia-derived exosomal miR-274 targets Sprouty in trachea and synaptic boutons to modulate growth and responses to hypoxia

Significance Our study provides significant advances in the understanding of circulating exosomal microRNA (miRNA) in animals. Circulating exosomal miRNAs mediate communication among tissues and organs. In glia, mature miR-274 is produced and secreted to the circulating hemolymph to target the recipient cells, neurons, and tracheal cells. We also identified the target gene sty whose expression is down-regulated by miR-274 in the target/recipient...