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Cheng-Ting Chien
Academia Sinica
59Publications
26H-index
3,923Citations
Publications 60
Newest
#1Yi-Wei Tsai (AS: Academia Sinica)
#2Hsin-Ho Sung (AS: Academia Sinica)
Last.Cheng-Ting Chien (AS: Academia Sinica)H-Index: 26
view all 9 authors...
Secreted exosomal microRNAs (miRNAs) mediate interorgan/tissue communications by modulating target gene expression, thereby regulating developmental and physiological functions. However, the source, route, and function in target cells have not been formally established for specific miRNAs. Here, we show that glial miR-274 non-cell-autonomously modulates the growth of synaptic boutons and tracheal branches. Whereas the precursor form of miR-274 is expressed in glia, the mature form of miR-274 dis...
1 CitationsSource
#1Pei-Yi Chen (AS: Academia Sinica)H-Index: 2
#2Yi-Wei Tsai (AS: Academia Sinica)
Last.Cheng-Ting Chien (AS: Academia Sinica)H-Index: 26
view all 5 authors...
Synaptic structure and activity are sensitive to environmental alterations. Modulation of synaptic morphology and function is often induced by signals from glia. However, the process by which glia mediate synaptic responses to environmental perturbations such as hypoxia remains unknown. Here, we report that, in the mutant for Trachealess (Trh), the Drosophila homolog for NPAS1 and NPAS3, smaller synaptic boutons form clusters named satellite boutons appear at larval neuromuscular junctions (NMJs...
1 CitationsSource
#1Wei-Kang Yang (AS: Academia Sinica)H-Index: 1
#2Yi-Ru Chueh (AS: Academia Sinica)H-Index: 1
Last.Cheng-Ting Chien (AS: Academia Sinica)H-Index: 26
view all 6 authors...
Summary Building sensory dendritic arbors requires branching, growth, spacing, and substrate support. The conserved L1CAM family of cell-adhesion molecules generates neuronal isoforms to regulate neurite development in various aspects. However, whether non-neuronal isoforms participate in any of these aspects is unclear. In Drosophila, the L1CAM homolog Neuroglian (Nrg) is expressed as two isoforms: the neuronal isoform Nrg180 on dendritic surfaces of dendritic arborization (da) neurons and the ...
1 CitationsSource
#1Wei-Kang Yang (AS: Academia Sinica)H-Index: 1
#2Cheng-Ting Chien (AS: Academia Sinica)H-Index: 26
Sensing environmental cues requires well-built neuronal circuits linked to the body surface. Sensory neurons generate dendrites to innervate surface epithelium, thereby making it the largest sensor...
2 CitationsSource
#1Cheng-Ting Chien (AS: Academia Sinica)H-Index: 26
#2Pei-Yi Chen (NYMU: National Yang-Ming University)H-Index: 2
view all 4 authors...
Synaptic structure and activity are sensitive to environmental alterations. Modulation of synaptic morphology and function is often induced by signals from glia. However, the process by which glia mediate synaptic responses to environmental perturbations such as hypoxia remains unknown. Here, we report that, in the Drosophila trachealess (trh) mutant, smaller synaptic boutons form clusters named bunch boutons appear at larval neuromuscular junctions (NMJs), which is induced by the reduction of i...
Source
#1Vanitha Nithianandam (NDMC: National Defense Medical Center)H-Index: 1
#2Cheng-Ting Chien (NDMC: National Defense Medical Center)H-Index: 26
The actin cytoskeleton provides structural stability and adaptability to the cell. Neuronal dendrites frequently undergo morphological changes by emanating, elongating, and withdrawing branches. However, the knowledge about actin dynamics in dendrites during these processes is limited. By performing in vivo imaging of F-actin markers, we found that F-actin was highly dynamic and heterogeneously distributed in dendritic shafts with enrichment at terminal dendrites. A dynamic F-actin population th...
11 CitationsSource
#1Chien-Po Liao (NTU: National Taiwan University)H-Index: 3
#2Hsun Li (AS: Academia Sinica)H-Index: 3
Last.Chun-Liang Pan (NTU: National Taiwan University)H-Index: 13
view all 5 authors...
Summary Self-avoidance allows sister dendrites from the same neuron to form non-redundant coverage of the sensory territory and is important for neural circuitry functions. Here, we report an unexpected, cell-autonomous role of the Wnt-secretory factor MIG-14/Wntless in mediating dendrite self-avoidance in the C. elegans multidendritic PVD neurons. Similar findings in Drosophila suggest that this novel function of Wntless is conserved. The mig-14 mutant shows defects in dendrite self-avoidance, ...
7 CitationsSource
Source
#1Wei-Kang YangH-Index: 1
#2Yi-Ru ChuehH-Index: 1
Last.Cheng-Ting ChienH-Index: 26
view all 4 authors...
Source
#1Chien-Hsiang Wang (AS: Academia Sinica)H-Index: 3
#2Yi-Chun Huang (AS: Academia Sinica)H-Index: 5
Last.Cheng-Ting Chien (AS: Academia Sinica)H-Index: 26
view all 7 authors...
Synapse formation and growth are tightly controlled processes. How synaptic growth is terminated after reaching proper size remains unclear. Here, we show that Leon, the Drosophila USP5 deubiquitinase, controls postsynaptic growth. In leon mutants, postsynaptic specializations of neuromuscular junctions are dramatically expanded, including the subsynaptic reticulum, the postsynaptic density, and the glutamate receptor cluster. Expansion of these postsynaptic features is caused by a disruption of...
9 CitationsSource
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