PARP1 blockade is synthetically lethal in XRCC1 deficient sporadic epithelial ovarian cancers
Abstract
PARP1 inhibitor (Niraparib, Olaparib, Rucaparib) maintenance therapy improves progression-free survival in platinum sensitive sporadic epithelial ovarian cancers. However, biomarkers of response to PARPi therapy is yet to be clearly defined. XRCC1, a scaffolding protein, interacts with PARP1 during BER and SSBR. In a large clinical cohort of 525 sporadic ovarian cancers, high XRCC1 or high PARP1 protein levels was not only associated with...
Paper Details
Title
PARP1 blockade is synthetically lethal in XRCC1 deficient sporadic epithelial ovarian cancers
Published Date
Jan 1, 2020
Journal
Volume
469
Pages
124 - 133
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