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Srinivasan Madhusudan
University of Nottingham
CancerDNA repairCancer researchBreast cancerMedicine
166Publications
33H-index
5,401Citations
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Publications 166
Newest
#1Silvana Tivadar (University of Nottingham)
#2Richard S. McIntosh (University of Nottingham)H-Index: 15
Last. Mireille Vankemmelbeke (University of Nottingham)H-Index: 12
view all 9 authors...
Tumor glycans constitute attractive targets for therapeutic antibodies. The sialylated glycocalyx plays a prominent role in cancer progression and immune evasion. Here we describe the characterization of the monoclonal antibody, FG129, which targets tumor-associated sialylated glycan and demonstrate its potential for multimodal cancer therapy. FG129, obtained through BALB/c mouse immunizations with liposomes containing membrane glycan extracts from the colorectal cancer cell line LS180, is a mIg...
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#1Reem Ali (University of Nottingham)H-Index: 4
#2Muslim Alabdullah (University of Nottingham)H-Index: 3
Last. Srinivasan Madhusudan (University of Nottingham)H-Index: 33
view all 9 authors...
ABSTRACT PARP1 inhibitor (Niraparib, Olaparib, Rucaparib) maintenance therapy improves progression-free survival in platinum sensitive sporadic epithelial ovarian cancers. However, biomarkers of response to PARPi therapy is yet to be clearly defined. XRCC1, a scaffolding protein, interacts with PARP1 during BER and SSBR. In a large clinical cohort of 525 sporadic ovarian cancers, high XRCC1 or high PARP1 protein levels was not only associated with aggressive phenotypes but was also significantly...
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#1Reem Ali (University of Nottingham)H-Index: 4
#2Muslim Alabdullah (University of Nottingham)H-Index: 3
Last. Srinivasan Madhusudan (University of Nottingham)H-Index: 33
view all 8 authors...
Ataxia-telegiectasia mutated (ATM), phosphatase and tensin homolog (PTEN), and p85α are key tumour suppressors. Whether ATM regulates PTEN expression and influence platinum sensitivity is unknown. We generated ATM knockdowns (KD) and CRISPR knock outs (KO) in glioblastoma (LN18, LN229) and ovarian cancer cells (OVCAR3, OVCAR4). Doxycycline inducible PTEN expression was generated in LN18 and LN229 cells. Transient KD of p85α, CK2, and XIAP was accomplished using siRNAs. Stable p85α knock-in was i...
1 CitationsSource
#1Tarek M. A. Abdel-Fatah (University of Nottingham)H-Index: 15
#2Reem Ali (University of Nottingham)H-Index: 4
Last. Srinivasan Madhusudan (University of Nottingham)H-Index: 33
view all 10 authors...
Genomic instability could be a beneficial predictor for anthracycline or taxane chemotherapy. We interrogated 188 DNA repair genes in the METABRIC cohort (n = 1980) to identify genes that influence overall survival (OS). We then evaluated the clinicopathological significance of ERCC1 in early stage breast cancer (BC) (mRNA expression (n = 4640) and protein level, n = 1650 (test set), and n = 252 (validation)) and in locally advanced BC (LABC) (mRNA expression, test set (n = 2340) and validation ...
3 CitationsSource
#1Muslim Alabdullah (University of Nottingham)H-Index: 3
#2Dena Ahmad (University of Nottingham)H-Index: 2
Last. Emad A. Rakha (University of Nottingham)H-Index: 54
view all 6 authors...
AbstractOvarian cancer is associated with the highest mortality rate among gynaecologic malignancies. There is a need to refine the classification of ovarian cancer and identify novel targets. The ...
1 CitationsSource
#1Katia A. Mesquita (University of Nottingham)H-Index: 2
#2Muslim Alabdullah (University of Nottingham)H-Index: 3
Last. Srinivasan Madhusudan (University of Nottingham)H-Index: 33
view all 10 authors...
Abstract Purpose PARP inhibitor maintenance therapy in platinum sensitive sporadic ovarian cancers improves progression free survival. However, biomarker for synthetic lethality in platinum sensitive sporadic disease is yet to be defined. ERCC1-XPF heterodimer is a key player in nucleotide excision repair (NER) involved in the repair of platinum induced DNA damage. In the current study, we tested whether ERCC1-XPF deficiency would predict synthetic lethality to the PARP inhibitor Olaparib and pl...
2 CitationsSource
#1Philip Kaye (University of Nottingham)H-Index: 21
#2Daniel Lindsay (University of Nottingham)H-Index: 2
Last. Krish Ragunath (University of Nottingham)H-Index: 42
view all 7 authors...
AIMS: There is evidence that four or five gastric cancer biopsies are required for accurate HER2 interpretation. However, the number of biopsies that need to be taken to reach this number of viable cancer biopsies is without evidence. This study aimed to address this gap by assessing the number of biopsies required to gain at least four viable biopsies containing cancer. METHODS AND RESULTS: A total of 105 consecutive biopsy cases of gastric and oesophageal adenocarcinoma were retrieved from fil...
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#1Constantinos Savva (University of Southampton)
#2Jason Adhikaree (University of Nottingham)H-Index: 2
Last. Kamal Chokkalingam (NUH: Nottingham University Hospitals NHS Trust)H-Index: 2
view all 4 authors...
Objectives Oncogenic osteomalacia is a rare paraneoplastic metabolic syndrome that is characterised by severe hypophosphataemia, hyperphosphaturia and osteomalacia secondary to renal loss of phosphate. It is commonly caused by overproduction of fibroblast growth factor-23 (FGF23) from benign tumours of mesenchymal origin. Currently, there is no clear evidence on the management of oncogenic osteomalacia in patients with metastatic solid tumours.
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#1Charles S. Fuchs (Yale Cancer Center)H-Index: 127
#2Kohei ShitaraH-Index: 31
Last. Timothy R. AsmisH-Index: 1
view all 144 authors...
Summary Background VEGF and VEGF receptor 2 (VEGFR-2)-mediated signalling and angiogenesis can contribute to the pathogenesis and progression of gastric cancer. We aimed to assess whether the addition of ramucirumab, a VEGFR-2 antagonist monoclonal antibody, to first-line chemotherapy improves outcomes in patients with metastatic gastric or gastro-oesophageal junction adenocarcinoma. Methods For this double-blind, randomised, placebo-controlled, phase 3 trial done at 126 centres in 20 countries,...
15 CitationsSource
#1Constantinos Savva (University of Nottingham)H-Index: 2
#2Karen De Souza (University of Nottingham)H-Index: 1
Last. Srinivasan Madhusudan (University of Nottingham)H-Index: 33
view all 6 authors...
Purpose MYC transcription factor has critical roles in cell growth, proliferation, metabolism, differentiation, transformation and angiogenesis. MYC overexpression is seen in about 15% of breast cancers and linked to aggressive phenotypes. MYC overexpression also induces oxidative stress and replication stress in cells. ATM signalling and ATR-mediated signalling are critical for MYC-induced DNA damage response. Whether ATM and ATR expressions influence clinical outcomes in MYC overexpressed brea...
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