Synaptic, axonal damage and inflammatory cerebrospinal fluid biomarkers in neurodegenerative dementias

Introduction Synaptic damage, axonal neurodegeneration, and neuroinflammation are common features in Alzheimer's disease (AD), frontotemporal dementia (FTD), and Creutzfeldt‐Jakob disease (CJD). Methods Unicentric cohort of 353 participants included healthy control (HC) subjects, AD continuum stages, genetic AD and FTD, and FTD and CJD. We measured cerebrospinal fluid neurofilament light (NF‐L), neurogranin (Ng), 14‐3‐3, and YKL‐40 proteins....