Fabrication of biodegradable Mn-doped mesoporous silica nanoparticles for pH/redox dual response drug delivery

Mn-doped mesoporous silica (MMS) nanocarriers were prepared by in situ doping Mn component for drug delivery. In the acidic or reductive microenvironment of tumor, the MnO bond can be broken up, and Mn components would be released from the silica framework, thus accelerating the degradation of the silica nanocarrier. Due to the mesoporous structure, MMS nanocarriers have a high specific surface area of 1125.56 m2/g, which is suitable for loading...