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Xu Zhang
Henan University
NanoparticleControlled releaseOrganic chemistryNanocarriersDrug delivery
7Publications
4H-index
34Citations
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Publications 9
Newest
#1Xinli Li (Henan University)
#2Yunyun Chen (Henan University)
Last. Yanbao Zhao (Henan University)H-Index: 14
view all 4 authors...
Abstract In this work, disulfide-bridged organic silica (OS) based nanocarriers were constructed for drug release. The broken of S S bonds in Si-O-Si skeleton would improve the degradation of Si-O-Si of OS carriers. The OS carriers have a central-radiated dendritic porous structure and a large specific surface area of 453.80 m2g−1. The dextrin was selectively oxidized to dialdehyde dextrin (DAD) and then was modified on the surface of OS carriers by Schiff base bonds. Subsequently, cystamine (Cy...
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#1Yunyun Chen (Henan University)
#2Xinli Li (Henan University)
Last. Lei Sun (Henan University)H-Index: 11
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#1Xinli Li (Henan University)
#2Xu Zhang (Henan University)H-Index: 4
Last. Lei Sun (Henan University)H-Index: 11
view all 4 authors...
Abstract Mn-doped mesoporous silica (MMS) nanocarriers were prepared by in situ doping Mn component for drug delivery. In the acidic or reductive microenvironment of tumor, the Mn O bond can be broken up, and Mn components would be released from the silica framework, thus accelerating the degradation of the silica nanocarrier. Due to the mesoporous structure, MMS nanocarriers have a high specific surface area of 1125.56 m2/g, which is suitable for loading and controlled release of drug. And the ...
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#1Qianqian Zhang (Henan University)H-Index: 1
#2Jia Guo (Henan University)H-Index: 1
Last. Lei Sun (Henan University)H-Index: 11
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Abstract In this work, redox/enzyme-responsive fluorescent porous silica (pSiO2) nanoparticles (NPs) were constructed for drug delivery. The resultant pSiO2 NPs have large-pore core and mesoporous shell with size of 75 nm and present high specific surface area (605 m2 g−1). Oxidized glutathione (GSSG) as linker was conjugated on the surfaces of amino-functionalized porous silica (pSiO2-NH2) NPs by the amide bonds for redox-responsive drug release. Dox is served as model drugs to evaluate the rel...
4 CitationsSource
#1Xu ZhangH-Index: 4
#2Yanbao ZhaoH-Index: 14
Last. Lei SunH-Index: 11
view all 4 authors...
Abstract In this work, pH/redox-responsive silica-based nanocarriers were constructed for drug delivery. Lemon-like porous silica (L-pSiO 2 ) sample presents uniform sphere with size of 160–180 nm and processes thiol-functionalized center-radial inner pores and amine-functionalized shell. Cystine (Cys) molecules were conjugated on the surface of L-pSiO 2 to seal the drug-loaded pores. To minimize the premature release, ZnO quantum dots (QDs) were further used to seal the nanopores of pSiO 2 NSs,...
6 CitationsSource
#1Li Qiu (Henan University)H-Index: 3
#2W.F. Zhang (Henan University)H-Index: 6
Last. Lei Sun (Henan University)H-Index: 11
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Abstract pH/enzyme-responsive nanocarriers based on porous silica (pSiO2) nanospheres (NSs) were developed for controlled release of drug. The pSiO2 NSs present uniform spheres and have an average diameter of 100 nm. The pSiO2 NSs with high specific surface area (835 m2·g− 1) and the pore volume (1.24 cm3·g− 1) are suitable for drug loading and the loading capacity reaches to 29% for amoxicillin (AMX) model drug. In this system, protocatechuic acid (PCA) and L-glutamic acid (Glu) as linkers were...
1 CitationsSource
#1Zhijie Zhang (Henan University)H-Index: 4
#2Yunping Wu (Henan University)H-Index: 4
Last. Lei Sun (Henan University)H-Index: 11
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Abstract In order to developing a sort of flexible fibrous mats with outstanding and durable antibacterial activates, silver nanowires incorporated into polyvinyl alcohol (PVA) nanofibers were fabricated by electrospun method. Uniform Ag nanowires (NWs) were synthesized through a template-free method of solvothermal combined with polyol process, and then, they were dispersed in PVA solution. At last, Ag NWs embedded in PVA (Ag NWs/PVA) hybrid nanofibrous films were gained by electrospun of the m...
12 CitationsSource
#1Xu Zhang (Henan University)H-Index: 4
#2Yamin WangH-Index: 1
Last. Lei Sun (Henan University)H-Index: 11
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Abstract In this work, pH-sensitive “dual-switch” porous silica (pSiO2) nanoparticles (NPs) were constructed for drug delivery. Poly(acrylic acid) (PAA) was grafting onto the internal and external surfaces of amino groups functionalized porous silica (pSiO2-NH2) NPs by the amidation between the amino groups and the carboxyl groups of PAA for pH triggered drug release. The resultant pSiO2/PAA NPs have an average diameter of 50–60 nm and high specific surface area (914 m2·g− 1). To improve the loa...
6 CitationsSource
#1Xu Zhang (Henan University)H-Index: 4
#2Yanbao Zhao (Henan University)H-Index: 14
Last. Lei Sun (Henan University)H-Index: 11
view all 4 authors...
Abstract Thiol and amine difunctionalized porous silica (pSiO 2 -SH/NH 2 ) nanoparticles (NPs) were prepared by condensation. The obtained pSiO 2 -SH/NH 2 NPs present uniform spheres with size of 55 nm. Folic acid (FA) as a tumor targeting agent was conjugated on the surface of pSiO 2 NPs by amide linkage (pSiO 2 -SH/FA NPs), and captopril (Cap) as test drug was used to evaluate the releasing behavior. Results indicated that Cap is easily encapsulated into the pores of pSiO 2 -SH/FA NPs, which c...
5 CitationsSource
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