doi.org/10.1016/j.matbio.2019.09.003
Original paper

Role of hypoxia in skeletal muscle fibrosis: Synergism between hypoxia and TGF-β signaling upregulates CCN2/CTGF expression specifically in muscle fibers

..., Enrique Brandan
47
Matrix Biology4.50
Volume: 87, Pages: 48 - 65
Published: May 1, 2020
Abstract
Several skeletal muscle diseases are characterized by fibrosis, the excessive accumulation of extracellular matrix. Transforming growth factor-β (TGF-β) and connective tissue growth factor (CCN2/CTGF) are two profibrotic factors augmented in fibrotic skeletal muscle, together with signs of reduced vasculature that implies a decrease in oxygen supply. We observed that fibrotic muscles are characterized by the presence of positive nuclei for...
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Paper Details
Title
Role of hypoxia in skeletal muscle fibrosis: Synergism between hypoxia and TGF-β signaling upregulates CCN2/CTGF expression specifically in muscle fibers
DOI
doi.org/10.1016/j.matbio.2019.09.003
Published Date
May 1, 2020
Journal
Matrix Biology
Volume
87
Pages
48 - 65
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