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Matrix Biology
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#1Roger Valle-Tenney (UC: Pontifical Catholic University of Chile)H-Index: 1
Last. Enrique Brandan (UC: Pontifical Catholic University of Chile)H-Index: 42
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Abstract (not structured and no more than 200 words) Several skeletal muscle diseases are characterized by fibrosis, the excessive accumulation of extracellular matrix. Transforming growth factor-β (TGF-β) and connective tissue growth factor (CCN2/CTGF) are two profibrotic factors augmented in fibrotic skeletal muscle, together with signs of reduced vasculature that implies a decrease in oxygen supply. We observed that fibrotic muscles are characterized by the presence of positive nuclei for hyp...
2 CitationsSource
#1Rosanna PellicaniH-Index: 5
#2Evelina PolettoH-Index: 2
Last. Maurizio MongiatH-Index: 21
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Abstract Multimerin-2 is an extracellular matrix glycoprotein and member of the elastin microfibril interface-located (EMILIN) family of proteins. Multimerin-2 is deposited along blood vessels and we previously demonstrated that it regulates the VEGFA/VEGFR2 signaling axis and angiogenesis. However, its role in modulating vascular homeostasis remains largely unexplored. Here we identified Multimerin-2 as a key molecule required to maintain vascular stability. RNAi knockdown of Multimerin-2 in en...
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#1Elina Siljamäki (UTU: University of Turku)H-Index: 6
#2Pekka Rappu (UTU: University of Turku)H-Index: 5
Last. Jyrki Heino (UTU: University of Turku)H-Index: 47
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Abstract Cutaneous squamous cell carcinoma (cSCC) is the most common metastatic skin cancer, with increasing incidence worldwide. The molecular basis of cSCC progression to invasive and metastatic disease is still incompletely understood. Here, we show that fibroblasts and transforming growth factor-β (TGF-β) signaling promote laminin-332 synthesis in cancer cells in an activated H-Ras-dependent manner, which in turn promotes cancer cell invasion. Immunohistochemical analysis of sporadic UV-indu...
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#1Yukimasa Taniguchi (Osaka University)H-Index: 9
#2Mamoru Takizawa (Osaka University)H-Index: 3
Last. Kiyotoshi Sekiguchi (Osaka University)H-Index: 53
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Abstract Laminins are major cell-adhesive proteins consisting of α, β, and γ chains, in which the three C-terminal globular domains of the α chain (LMα/LG1–3) and the C-terminal tail region of the γ1 chain (LMγ1-tail) are required for binding to integrin. Despite the recent progress on the role of LMγ1-tail in coordinating the metal ion-dependent adhesion site of the integrin β subunit, the mechanism by which LMα/LG1–3 interacts with integrin remains to be elucidated. We found that basic residue...
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#1Shamima Islam (Aichi Medical University)H-Index: 13
#2Kantinan Chuensirikulchai (Aichi Medical University)
Last. Hideto Watanabe (Aichi Medical University)H-Index: 26
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Abstract Versican is a large chondroitin sulfate/dermatan sulfate proteoglycan in the extracellular matrix, and is expressed at high levels in tissues during development and remodeling in pathological conditions. Its core protein is cleaved at a region close to the N-terminal end of CSβ domain by several members of a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) family, i.e., ADAMTS-1, 4, 5, 9, 15, and 20. Here, using a CRISPR/Cas9 system, we generated knock-in mice (V1R)...
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#1Steven Tessier (Thomas Jefferson University)H-Index: 1
#2Victoria A. Tran (Thomas Jefferson University)H-Index: 1
Last. Makarand V. Risbud (Thomas Jefferson University)H-Index: 45
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Abstract The tonicity-responsive enhancer binding protein (TonEBP) plays an important role in intervertebral disc and axial skeleton embryogenesis. However, the contribution of this osmoregulatory transcription factor in postnatal intervertebral disc homeostasis is not known in vivo. Here, we show for the first time that TonEBP-deficient mice have pronounced age-related degeneration of the intervertebral disc with annular and endplate herniations. Using FTIR-imaging spectroscopy, quantitative im...
1 CitationsSource
#1Velina Bachvarova (University of Duisburg-Essen)H-Index: 6
#2Tabea Dierker (Uppsala University)H-Index: 5
Last. Andrea Vortkamp (University of Duisburg-Essen)H-Index: 34
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Abstract Heparan sulfate (HS) regulates the activity of many signaling molecules critical for the development of endochondral bones. Even so, mice with a genetically altered HS metabolism display a relatively mild skeletal phenotype compared to the defects observed in other tissues and organs pointing to a reduced HS dependency of growth-factor signaling in chondrocytes. To understand this difference, we have investigated the glycosaminoglycan (GAG) composition in two mouse lines that produce ei...
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#1Francesca Tonelli (UNIPV: University of Pavia)H-Index: 3
#2Silvia Cotti (UNIPV: University of Pavia)
Last. Raimund Wagener (University of Cologne)H-Index: 28
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Abstract Prolyl 3-hydroxylation is a rare collagen type I post translational modification in fibrillar collagens. The primary 3Hyp substrate sites in type I collagen are targeted by an endoplasmic reticulum (ER) complex composed by cartilage associated protein (CRTAP), prolyl 3-hydroxylase 1 (P3H1) and prolyl cis/trans isomerase B, whose mutations cause recessive forms of osteogenesis imperfecta with impaired levels of α1(I)3Hyp986. The absence of collagen type I 3Hyp in wild type zebrafish prov...
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#1Mahbubul H. Shihan (UD: University of Delaware)H-Index: 2
#2Mallika Kanwar (UD: University of Delaware)
Last. Melinda K. Duncan (UD: University of Delaware)H-Index: 32
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Abstract Fibrotic posterior capsular opacification (PCO), one of the major complications of cataract surgery, occurs when lens epithelial cells (LCs) left behind post cataract surgery (PCS) undergo epithelial to mesenchymal transition, migrate into the optical axis and produce opaque scar tissue. LCs left behind PCS robustly produce fibronectin, although its roles in fibrotic PCO are not known. In order to determine the function of fibronectin in PCO pathogenesis, we created mice lacking the fib...
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#1Michael J. Randles (MAHSC: Manchester Academic Health Science Centre)
#1Michael J. Randles (MAHSC: Manchester Academic Health Science Centre)H-Index: 7
Last. Rachel Lennon (MAHSC: Manchester Academic Health Science Centre)
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Abstract Cells have evolved mechanisms to sense the composition of their adhesive microenvironment. Although much is known about general mechanisms employed by adhesion receptors to relay signals between the extracellular environment and the cytoskeleton, the nuances of ligand-specific signalling remain undefined. Here, we investigated how glomerular podocytes, and four other basement membrane-associated cell types, respond morphologically to different basement membrane ligands. We defined the c...
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Top fields of study
Molecular biology
Extracellular matrix
Biochemistry
Biology
Cell biology