Review paper
Emergence of allosteric drug-resistance mutations: new challenges for allosteric drug discovery
Abstract
Allosteric drugs have several significant advantages over traditional orthosteric drugs, encompassing higher selectivity and lower toxicity. Although allosteric drugs have potential advantages as therapeutic agents to treat human diseases, allosteric drug-resistance mutations still occur, rendering these drugs ineffective. Here, we review the emergence of allosteric drug-resistance mutations with an emphasis on examples covering clinically...
Paper Details
Title
Emergence of allosteric drug-resistance mutations: new challenges for allosteric drug discovery
Published Date
Jan 1, 2020
Journal
Volume
25
Issue
1
Pages
177 - 184
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