Perioperative omega-3 fatty acids fail to confer protection in liver surgery: Results of a multicentric, double-blind, randomized controlled trial

•Perioperative intravenous infusions of omega-3 fatty acids failed to confer a benefit in this RCT.•No differences in complications were evident in the Omegaven vs. Placebo groups.•Subgroup analyses likewise did not detect differences in outcomes after liver resection. Background & AimsIn a variety of animal models, omega-3 polyunsaturated fatty acids (Ω3-FAs) conferred strong protective effects, alleviating hepatic ischemia/reperfusion injury...