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Journal of Hepatology
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#1Michael Trauner (Medical University of Vienna)H-Index: 76
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Abstract The current pandemic coronavirus labelled as Severe Acute Respiratory Distress Syndrome Coronavirus -2 (SARS -CoV-2) is a significant public health threat over for past few weeks. Overall case fatality rates range between 2-6%; however, the rates are higher in patients with severe disease, advanced age and underlying comorbidities like diabetes, hypertension and heart disease. Recent reports showed about 2-11% of patients with COVID-19 had underlying chronic liver disease. Experience fr...
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#1Sang Hyun Choi (UOU: University of Ulsan)H-Index: 8
#2So Yeon Kim (UOU: University of Ulsan)H-Index: 30
Last. Young-Suk Lim (UOU: University of Ulsan)H-Index: 33
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#1Anita Paisant (University of Angers)H-Index: 3
#2Valérie Vilgrain (Paris Diderot University)H-Index: 72
Last. Christophe Aubé (University of Angers)H-Index: 27
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#1Inderbhan Singh (PGIMER: Post Graduate Institute of Medical Education and Research)
#2Arka De (PGIMER: Post Graduate Institute of Medical Education and Research)H-Index: 2
Last. Virendra Singh (PGIMER: Post Graduate Institute of Medical Education and Research)H-Index: 21
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#1Ravi P. Rai (University of Pittsburgh)H-Index: 1
#2Yunshan Liu (Emory University)H-Index: 12
Last. Asma Nusrat (UM: University of Michigan)H-Index: 67
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Abstract Background & Aims The heterodimeric integrin receptor α4β7 regulates CD4 T cell recruitment to inflamed tissues, but its role in the pathogenesis of nonalcoholic steatohepatitis (NASH) is unknown. Here we examined the role of α4β7-mediated recruitment of CD4 T cells to the intestine and liver in NASH. Methods Male littermate F11r+/+ (control) and junctional adhesion molecule A knockout F11r–/– mice were fed a normal diet or a Western diet (WD) for eight weeks. Liver and intestinal tissu...
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#1Teresa Brevini (Medical Research Council)H-Index: 1
#2Olivia C Tysoe (University of Cambridge)H-Index: 1
Last. Fotios Sampaziotis (University of Cambridge)H-Index: 8
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Abstract Our insight into the pathogenesis of cholestatic liver disease remains limited, partly due to challenges in capturing the multitude of factors contributing to the disease pathogenesis in vitro. Tissue engineering could address this challenge by combining cells, materials and fabrication strategies into dynamic modelling platforms, recapitulating the multifaceted aetiology of cholangiopathies. Here we review different platforms for bioengineering the biliary tree, their advantages and li...
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#1Sabela Lens (University of Barcelona)H-Index: 19
#2Anna Baiges (University of Barcelona)H-Index: 8
Last. A. GallegoH-Index: 9
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Abstract Background Clinically significant portal hypertension (CSPH, HVPG≥10mmHg) persists 24 weeks after sustained virological response (SVR) in up to 78% of patients with HCV-related cirrhosis treated with direct acting antivirals. These patients remain at risk of decompensation. However, long-term paired clinical and hemodynamic data are not available for this population. Methods Multicenter prospective study including 226 patients with HCV-related cirrhosis and CSPH achieving SVR after anti...
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#1Antonio Saviano (UDS: University of Strasbourg)H-Index: 2
#2Neil C. Henderson (Edin.: University of Edinburgh)H-Index: 24
Last. Thomas BaumertH-Index: 35
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SUMMARY Transcriptome analysis allows the study of gene expression of human tissues and it is a valuable tool to characterize liver function, gene expression changes during liver disease, identify prognostic markers or signatures, and to facilitate discovery of new therapeutic targets. In contrast to whole tissue RNA sequencing analysis, single-cell RNA-sequencing (scRNA-seq) and spatial transcriptomics enables the study of transcriptional activity at the single cell or spatial level. ScRNA-seq ...
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Top fields of study
Virology
Hepatitis C
Cirrhosis
Diabetes mellitus
Medicine
Gastroenterology