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Journal of Hepatology
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18.95
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37160
Papers 37112
1 page of 3,712 pages (37.1k results)
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#1Dafna Groeneveld (MSU: Michigan State University)H-Index: 8
#2Holly Cline Fedewa (MSU: Michigan State University)
Last.James P. Luyendyk (MSU: Michigan State University)H-Index: 30
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Abstract Background & Aim Acetaminophen (APAP)-induced acute liver failure is associated with substantial alterations in the hemostatic system. In mice, platelets accumulate in the liver after APAP overdose and appear to promote liver injury. Interestingly, patients with acute liver injury have highly elevated levels of the platelet-adhesive protein von Willebrand factor (VWF), but a mechanistic connection between VWF and progression of liver injury has not been established. We tested the hypoth...
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#1Mohammad S. Siddiqui (VCU: Virginia Commonwealth University)H-Index: 15
#2Mark L. Van Natta (Johns Hopkins University)H-Index: 38
Last.Arun J. Sanyal (VCU: Virginia Commonwealth University)H-Index: 102
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Abstract Background Farnesoid X receptor (FXR) agonist, obeticholic acid (OCA), increases total and low-density lipoprotein cholesterol (LDL-C) in patients with nonalcoholic steatohepatitis (NASH). The present study evaluated the impact of OCA therapy on lipoprotein sub-particles. Method The study included 196 patients (99 OCA group and 97 placebo) who were enrolled in the FLINT trial and had samples available for lipid analysis and liver biopsies at enrollment and end-of-treatment (EOT) at 72 w...
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#1William Bernal (University of Cambridge)H-Index: 38
#2Stephen H. Caldwell (UVA: University of Virginia)H-Index: 52
Last.Ton Lisman (UMCG: University Medical Center Groningen)H-Index: 51
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#1Fangjie Jiang (Fudan University)
#2Qi Chen (Fudan University)
Last.Pu Xia (Fudan University)H-Index: 1
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Abstract Background and Aims Clinical evidence has indicated a close relationship between non-alcoholic fatty liver disease (NAFLD) and cardiovascular diseases (CVD). However, the underlying mechanism remains to be elucidated. This study aimed to explore a potential role of hepatocyte-derived extracellular vesicles (EVs) in endothelial inflammation and atherogenesis under NAFLD status. Methods and Results By using an endothelial cell-specific PCR array, we identified that hepatocyte-derived EVs ...
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Top fields of study
Virology
Hepatitis C
Cirrhosis
Diabetes mellitus
Medicine
Gastroenterology