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Journal of Hepatology
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18.95
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37015
Papers 36978
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#1Sergio Borgia (Brampton Civic Hospital)H-Index: 6
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Abstract Background & Aims Although off-label use of sofosbuvir-containing regimens occurs regularly in patients with hepatitis C virus (HCV) infection undergoing dialysis for severe renal impairment or end-stage renal disease (ESRD), these regimens are not licensed for this indication, and there is an absence of dosing recommendations in this population. This study evaluated the safety and efficacy of sofosbuvir/velpatasvir in patients with HCV infection with ESRD undergoing dialysis. Methods I...
#1Jingxiao Wang (Beijing University of Chinese Medicine)H-Index: 3
#2Haichuan Wang (Sichuan University)H-Index: 2
Last.Xinyan Chen (UCSF: University of California, San Francisco)
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Abstract Background & Aims The ubiquitin ligase F-box and WD repeat domain-containing 7 (FBXW7) is recognized as a tumor suppressor in many cancer types due to its ability to promote the degradation of numerous oncogenic target proteins. Methods : Here, we investigated the role of FBXW7 in intrahepatic cholangiocarcinoma (iCCA) using mouse models ad hoc generated, iCCA cell lines, and human iCCA specimens. Results : FBXW7 mRNA expression is almost ubiquitously downregulated in human iCCA specime...
#1Gevitha Ravichandran (UHH: University of Hamburg)H-Index: 1
#2Katrin Neumann (UHH: University of Hamburg)H-Index: 2
Last.Leonard U. Hess (Heinrich Pette Institute)H-Index: 2
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Abstract Background and Aims Primary sclerosing cholangitis (PSC) is an idiopathic, chronic cholestatic liver disorder characterized by biliary inflammation and fibrosis. Increased numbers of intrahepatic interferon-γ- (IFNγ) producing lymphocytes have been documented in patients with PSC, yet their functional role remains to be determined. Methods Liver tissue samples were collected from patients with PSC. The contribution of lymphocytes to liver pathology was assessed in Mdr2 −/− x Rag1 −/− mi...
#1S. Yang (HUST: Huazhong University of Science and Technology)
#2Lu Wang (HUST: Huazhong University of Science and Technology)H-Index: 1
Last.Qing Yu (HUST: Huazhong University of Science and Technology)H-Index: 2
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Abstract Background & Aims CD100 is constitutively expressed on T cells and can be cleaved from the cell surface by matrix metalloproteases (MMPs) to become soluble CD100 (sCD100). Both membrane-bound CD100 (mCD100) and sCD100 play important immune regulatory functions that promote immune cell activation and responses. The aim of this study was to investigate the expression and role of mCD100 and sCD100 in regulating antiviral immune responses during HBV infection. Methods mCD100 expression on T...
#1Valerio Nobili (Sapienza University of Rome)H-Index: 49
Last.Giovanni TargherH-Index: 58
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Abstract Background & Aims We undertook a cross-sectional study of children/adolescents with and without non-alcoholic fatty liver disease (NAFLD) to compare the prevalence of prediabetes and diabetes, and to examine the role of abnormal glucose tolerance as a predictor of liver disease severity. Methods We recruited a cohort of 599 Caucasian children/adolescents with biopsy-proven NAFLD, and 118 children/adolescents without NAFLD, who were selected to be similar for age, sex, body mass index an...
#1Zobair M. Younossi (Inova Health System)H-Index: 75
#2Pegah Golabi (Inova Health System)H-Index: 8
Last.Fatema NaderH-Index: 20
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Abstract Background and Aims Although Non-alcoholic fatty liver disease (NAFLD), Non-alcoholic steatohepatitis (NASH) and NASH with advanced fibrosis are closely associated with type 2 diabetes mellitus (T2DM), their global prevalence rates have not been not well described. Our aim was to estimate the prevalence of NAFLD, NASH, and advanced fibrosis among T2DM patients by regions of the world. Methods PubMed, Ovid-Medline, EMBASE and Web of Science were searched from January 1989 to September 20...
#1Guoying Zhou (EUR: Erasmus University Rotterdam)H-Index: 3
#2Dave Sprengers (EUR: Erasmus University Rotterdam)H-Index: 19
Last.Valeska de Ruiter (EUR: Erasmus University Rotterdam)
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Abstract Background & Aims Cholangiocarcinoma is an aggressive hepatobiliary malignancy originating from biliary tract epithelium. Whether cholangiocarcinoma is responsive to immune checkpoint antibody therapy is unknown, and knowledge of its tumor immune microenvironment is limited. We aimed to characterize tumor-infiltrating lymphocytes (TIL) in cholangiocarcinoma and assess functional effects of targeting checkpoint molecules on TIL. Methods We isolated TIL from resected tumors of cholangioca...
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