P4-345: CAROTID ARTERY STENOSIS IN RELATION TO BRAIN TISSUE VOLUMES AND WHITE MATTER MICROSTRUCTURE: AN INTERHEMISPHERIC COMPARISON IN COMMUNITY DWELLING INDIVIDUALS

Low cerebral perfusion is a risk factor for dementia, and may represent a novel target for intervention against cognitive decline. Carotid artery stenosis is a common cause of haemodynamic impairment of cerebral blood flow, but its association with neurodegeneration remains uncertain. From the population-based Rotterdam Study, we included all consecutive participants who underwent structural brain magnetic resonance (MR) imaging and...