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Frank J. Wolters
Erasmus University Rotterdam
Rotterdam StudyHazard ratioDementiaPopulationMedicine
73Publications
15H-index
851Citations
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Publications 74
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#1Robert Hurford (University of Oxford)H-Index: 1
#2Frank J. Wolters (EUR: Erasmus University Rotterdam)H-Index: 15
Last. Peter M. Rothwell (University of Oxford)H-Index: 108
view all 5 authors...
Introduction Intracranial stenosis (ICS) is believed to convey a high risk of recurrent ischaemic stroke, but the SAMMPRIS trial failed to show superiority of ICS stenting over intensive medical management. However, the risk of recurrent stroke in the medical arm was low, leading to questions about generalisability. We studied the long-term risk of recurrent stroke in patients with ICS in a population-based setting. Methods Patients with TIA or minor stroke [NIHSS £3] underwent MRA in the Oxford...
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#1Yuan Ma (Harvard University)
#2Frank J. Wolters (EUR: Erasmus University Rotterdam)H-Index: 15
Last. M. Kamran Ikram (EUR: Erasmus University Rotterdam)H-Index: 39
view all 7 authors...
Background Variation in blood pressure may relate to dementia risk via autonomic disturbance or hemodynamic mechanisms, but the long-term associations are unclear. We aimed to determine whether blood pressure variation over a period of years, considering both magnitude and direction, is associated with the risk of dementia. Methods and findings In a prospective cohort study ongoing since 1989 in the Netherlands, 5,273 dementia-free participants (58.1% women; mean [SD] age, 67.6 [8.0] years) were...
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#1Sirwan K.L. Darweesh (EUR: Erasmus University Rotterdam)H-Index: 13
#2Silvan Licher (EUR: Erasmus University Rotterdam)H-Index: 8
Last. M. Arfan Ikram (EUR: Erasmus University Rotterdam)H-Index: 82
view all 6 authors...
Abstract Introduction Poor gait has recently emerged as a potential prodromal feature of cognitive decline and dementia. We assessed to what extent various aspects of poor gait are independently associated with cognitive decline and incident dementia. Methods We leveraged detailed quantitative gait (GAITRite™) and cognitive assessments in 4258 dementia-free participants (median age 67 years, 55% women) of the population-based Rotterdam Study (baseline 2009–2013). We summarized 30 gait parameters...
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#1Hakim C. Achterberg (EUR: Erasmus University Rotterdam)H-Index: 5
#2Lauge Sørensen (UCPH: University of Copenhagen)H-Index: 13
Last. Marleen de Bruijne (UCPH: University of Copenhagen)H-Index: 30
view all 8 authors...
Hippocampal volume and shape are known magnetic resonance imaging biomarkers of neurodegeneration. Recently, hippocampal texture has been shown to improve prediction of dementia in patients with mild cognitive impairment, but it is unknown whether texture adds prognostic information beyond volume and shape and whether the predictive value extends to cognitively healthy individuals. Using 510 subjects from the Rotterdam Study, a prospective, population-based cohort study, we investigated if hippo...
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#1Frank J. Wolters (EUR: Erasmus University Rotterdam)H-Index: 15
#2Hazel I. Zonneveld (EUR: Erasmus University Rotterdam)H-Index: 5
Last. M. Arfan Ikram (EUR: Erasmus University Rotterdam)H-Index: 82
view all 8 authors...
Objective To determine the long-term association of hemoglobin levels and anemia with risk of dementia, and explore underlying substrates on brain MRI in the general population. Methods Serum hemoglobin was measured in 12,305 participants without dementia of the population-based Rotterdam Study (mean age 64.6 years, 57.7% women). We determined risk of dementia and Alzheimer disease (AD) (until 2016) in relation to hemoglobin and anemia. Among 5,267 participants without dementia with brain MRI, w...
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#1Frank J. Wolters (EUR: Erasmus University Rotterdam)H-Index: 15
#2Qiong Yang (BU: Boston University)H-Index: 48
Last. Sudha Seshadri (BU: Boston University)H-Index: 84
view all 18 authors...
Background Apolipoprotein E is a glycoprotein best known as a mediator and regulator of lipid transport and uptake. The APOE-e4 allele has long been associated with increased risks of Alzheimer's disease and mortality, but the effect of the less prevalent APOE-e2 allele on diseases in the elderly and survival remains elusive. Methods We aggregated data of 38,537 individuals of European ancestry (mean age 65.5 years; 55.6% women) from six population-based cohort studies (Rotterdam Study, AGES-Rey...
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#1Frank J. WoltersH-Index: 15
#2Saima Hilal (EUR: Erasmus University Rotterdam)H-Index: 2
Last. M. Arfan IkramH-Index: 82
view all 9 authors...
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#2Frank J. WoltersH-Index: 15
Last. M. Kamran IkramH-Index: 39
view all 7 authors...
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#1Silvan Licher (Harvard University)H-Index: 1
#2Maarten J.G. Leening (Harvard University)H-Index: 20
Last. M. Arfan Ikram (Harvard University)H-Index: 1
view all 12 authors...
Objective:Identification of individuals at high risk of dementia is essential for development of prevention strategies, but reliable tools are lacking for risk stratification in the population. The...
3 CitationsSource
#1Daniel BosH-Index: 18
#2Frank J. WoltersH-Index: 15
Last. M. Arfan IkramH-Index: 82
view all 8 authors...
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