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Frank J. Wolters
Erasmus University Rotterdam
70Publications
12H-index
640Citations
Publications 70
Newest
#1Hakim C. Achterberg (EUR: Erasmus University Rotterdam)H-Index: 3
#2Lauge Sørensen (UCPH: University of Copenhagen)H-Index: 10
Last.Marleen de Bruijne (UCPH: University of Copenhagen)H-Index: 32
view all 8 authors...
textabstractHippocampal volume and shape are known magnetic resonance imaging biomarkers of neurodegeneration. Recently, hippocampal texture has been shown to improve prediction of dementia in patients with mild cognitive impairment, but it is unknown whether texture adds prognostic information beyond volume and shape and whether the predictive value extends to cognitively healthy individuals. Using 510 subjects from the Rotterdam Study, a prospective, population-based cohort study, we investiga...
#1Sirwan K.L. Darweesh (EUR: Erasmus University Rotterdam)H-Index: 12
#2Silvan Licher (EUR: Erasmus University Rotterdam)H-Index: 6
Last.M. Arfan Ikram (EUR: Erasmus University Rotterdam)H-Index: 71
view all 6 authors...
Abstract Introduction Poor gait has recently emerged as a potential prodromal feature of cognitive decline and dementia. We assessed to what extent various aspects of poor gait are independently associated with cognitive decline and incident dementia. Methods We leveraged detailed quantitative gait (GAITRite™) and cognitive assessments in 4258 dementia-free participants (median age 67 years, 55% women) of the population-based Rotterdam Study (baseline 2009–2013). We summarized 30 gait parameters...
#1Frank J. Wolters (EUR: Erasmus University Rotterdam)H-Index: 12
#2Hazel I. Zonneveld (EUR: Erasmus University Rotterdam)H-Index: 5
Last.M. Arfan Ikram (EUR: Erasmus University Rotterdam)H-Index: 71
view all 8 authors...
Objective To determine the long-term association of hemoglobin levels and anemia with risk of dementia, and explore underlying substrates on brain MRI in the general population. Methods Serum hemoglobin was measured in 12,305 participants without dementia of the population-based Rotterdam Study (mean age 64.6 years, 57.7% women). We determined risk of dementia and Alzheimer disease (AD) (until 2016) in relation to hemoglobin and anemia. Among 5,267 participants without dementia with brain MRI, w...
The notion of what qualifies as vascular dementia has varied greatly since the first mention of dementia after apoplexy in ancient literature. Current insight points towards a multifactorial cause ...
#1Silvan Licher (Harvard University)
#2Maarten J.G. Leening (Harvard University)H-Index: 19
Last.M. Kamran Ikram (Harvard University)
view all 10 authors...
Objective:Identification of individuals at high risk of dementia is essential for development of prevention strategies, but reliable tools are lacking for risk stratification in the population. The authors developed and validated a prediction model to calculate the 10-year absolute risk of developing dementia in an aging population.Methods:In a large, prospective population-based cohort, data were collected on demographic, clinical, neuropsychological, genetic, and neuroimaging parameters from 2...
#1Frank J. Wolters (EUR: Erasmus University Rotterdam)H-Index: 12
#2Liselotte M Tinga (EUR: Erasmus University Rotterdam)
Last.M. Arfan Ikram (EUR: Erasmus University Rotterdam)H-Index: 71
view all 9 authors...
#1Frank J. WoltersH-Index: 12
#2Johan BoenderH-Index: 4
Last.M. Arfan IkramH-Index: 71
view all 10 authors...
Low ADAMTS13 activity is associated with an increased risk of cardiovascular disease, which is generally attributed to its proteolytic effects on Von Willebrand factor (VWF). Cardiovascular health is an important determinant of cognitive decline, but the association of either VWF or ADAMTS13 with risk of dementia is unknown. Between 1997-2002, we measured VWF antigen and ADAMTS13 activity in 6055 participants of the population-based Rotterdam Study (mean age 69.3 years, 57.2% women). At baseline...
#1Frank J. Wolters (EUR: Erasmus University Rotterdam)H-Index: 12
#2Johan Boender (EUR: Erasmus University Rotterdam)H-Index: 1
Last.M. Arfan Ikram (EUR: Erasmus University Rotterdam)H-Index: 71
view all 10 authors...
textabstractLow ADAMTS13 activity is associated with an increased risk of cardiovascular disease, which is generally attributed to its proteolytic effects on Von Willebrand factor (VWF). Cardiovascular health is an important determinant of cognitive decline, but the association of either VWF or ADAMTS13 with risk of dementia is unknown. Between 1997-2002, we measured VWF antigen and ADAMTS13 activity in 6055 participants of the population-based Rotterdam Study (mean age 69.3 years, 57.2% women)....
#1Daniel Bos (Harvard University)H-Index: 16
#2Frank J. Wolters (Harvard University)H-Index: 12
Last.Boer de H. A (Harvard University)H-Index: 224
view all 7 authors...
Abstract Introduction Cerebral small vessel disease is increasingly linked to dementia. Methods We systematically searched Medline, Embase, and Cochrane databases for prospective population-based studies addressing associations of white matter hyperintensities, covert brain infarcts (i.e., clinically silent infarcts), and cerebral microbleeds with risk of all-dementia or Alzheimer's disease and performed meta-analyses. Results We identified 11 studies on white matter hyperintensities, covert bra...
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