Refining classification of malignant pleural mesothelioma reveals its Achilles’ heel

Malignant pleural mesothelioma (MPM) is a rare but deadly form of cancer originating from mesothelial cells lining the pleural. It occurs over a wide age range, typically presented with diffuse pleural thickening associated with an effusion and the diagnosis is based on tissue biopsy. According to 2015 WHO classification, MPM is divided to three morphological subtypes, namely, epitheliod which accounts for 60–80% of MPMs, sarcomatoid and...