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Ioannis S. Pateras
National and Kapodistrian University of Athens
57Publications
19H-index
1,272Citations
Publications 57
Newest
#1Ioannis S. Pateras (UoA: National and Kapodistrian University of Athens)H-Index: 19
Source
#1Panagiota Economopoulou (UoA: National and Kapodistrian University of Athens)H-Index: 16
#2George Koutsodontis (UoA: National and Kapodistrian University of Athens)H-Index: 4
Last.Amanda Psyrri (UoA: National and Kapodistrian University of Athens)H-Index: 37
view all 14 authors...
Objectives Human papillomavirus-related oropharyngeal squamous cell carcinoma (HPV+ OPSCC) is increasing in incidence. Although HPV+ OPSCC has favorable prognosis, 10 to 25% of HPV+ OPSCCs eventually recur. We sought to evaluate the feasibility of detection of HPV16 E6/E7 expression in Circulating Tumor Cells (CTCs) and its utility as a prognostic tool in HPV16-associated OPSCC. Materials and methods We developed a highly sensitive RT-qPCR assay for HPV mRNA expression in EpCAM(+) CTCs. In 22 pa...
Source
#1Pavel N. Lobachevsky (University of Melbourne)H-Index: 15
#2Jessica Ventura (Royal Women's Hospital)H-Index: 3
Last.Olga A. Martin (University of Melbourne)H-Index: 21
view all 17 authors...
Purpose Nontargeted effects of ionizing radiation, by which unirradiated cells and tissues are also damaged, are a relatively new paradigm in radiobiology. We recently reported radiation-induced abscopal effects (RIAEs) in normal tissues; namely, DNA damage, apoptosis, and activation of the local and systemic immune responses in C57BL6/J mice after irradiation of a small region of the body. High-dose-rate, synchrotron-generated broad beam or multiplanar x-ray microbeam radiation therapy was used...
1 CitationsSource
#1Apostolos Pappas (UoA: National and Kapodistrian University of Athens)H-Index: 4
#2Sophia Magkouta (UoA: National and Kapodistrian University of Athens)H-Index: 8
Last.Ioannis Kalomenidis (UoA: National and Kapodistrian University of Athens)H-Index: 18
view all 9 authors...
ABSTRACTVersican promotes experimental tumor growth through cell- and non cell-autonomous mechanisms. Its role in mesothelioma progression has not been investigated so far. In this study we investigated the impact of tumor-derived versican in mesothelioma progression and the underlying mechanism of its action. For this purpose, versican-silenced or control ΑE17 and ΑΒ1 murine mesothelioma cells were intrapleuraly injected into syngeneic mice, in order to create pleural mesotheliomas and pleural ...
4 CitationsSource
#1Ioannis S. Pateras (UoA: National and Kapodistrian University of Athens)H-Index: 19
#2Tomer Cooks (BGU: Ben-Gurion University of the Negev)H-Index: 1
Source
#1Alexandra Barbouti (UoI: University of Ioannina)H-Index: 11
#2Konstantinos Evangelou (UoI: University of Ioannina)H-Index: 18
Last.Vassilis G. Gorgoulis (University of Manchester)H-Index: 10
view all 10 authors...
Abstract Cellular senescence, an age-related process in response to damage and stress, also occurs during normal development and adult life. The thymus is a central lymphoepithelial organ of the immune system that exhibits age-related changes termed thymic involution. Since the mechanisms regulating thymic involution are still not well elucidated, we questioned whether cellular senescence is implicated in this process. We demonstrate, for the first time in situ , that cellular senescence occurs ...
3 CitationsSource
In the era of precision medicine immunohistochemistry (IHC) and immunocytochemistry (ICC) share some of the highlights in personalized treatment. Survival data obtained from clinical trials shape the cut-offs and IHC scoring that serve as recommendations for patient selection both for targeted and conventional therapies. Assessment of Estrogen and Progesterone Receptors along with HER2 status has been among the first approved immunostaining assays revolutionizing breast cancer treatment. Similar...
#1Alice Lallo (University of Manchester)H-Index: 4
#2Sakshi Gulati (University of Manchester)H-Index: 11
Last.Caroline Dive (University of Manchester)H-Index: 66
view all 15 authors...
4 CitationsSource
#1Panagiotis Galanos (UoA: National and Kapodistrian University of Athens)H-Index: 4
#2George Pappas (UoA: National and Kapodistrian University of Athens)H-Index: 12
Last.Vassilis G. Gorgoulis (UoA: National and Kapodistrian University of Athens)H-Index: 47
view all 21 authors...
Background Genomic instability promotes evolution and heterogeneity of tumors. Unraveling its mechanistic basis is essential for the design of appropriate therapeutic strategies. In a previous study, we reported an unexpected oncogenic property of p21WAF1/Cip1, showing that its chronic expression in a p53-deficient environment causes genomic instability by deregulation of the replication licensing machinery.
15 CitationsSource
#1Tomer Cooks (NIH: National Institutes of Health)H-Index: 7
#2Ioannis S. Pateras (UoA: National and Kapodistrian University of Athens)H-Index: 19
Last.Curtis C. Harris (NIH: National Institutes of Health)H-Index: 132
view all 10 authors...
TP53 mutants (mutp53) are involved in the pathogenesis of most human cancers. Specific mutp53 proteins gain oncogenic functions (GOFs) distinct from the tumor suppressor activity of the wild-type protein. Tumor-associated macrophages (TAMs), a hallmark of solid tumors, are typically correlated with poor prognosis. Here, we report a non-cell-autonomous mechanism, whereby human mutp53 cancer cells reprogram macrophages to a tumor supportive and anti-inflammatory state. The colon cancer cells harbo...
49 CitationsSource
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