Genomic and Metabolomic Polymorphism among Experimentally Selected Paromomycin-Resistant Leishmania donovani Strains

C. D. Shaw; Hideo Imamura; Tim Downing; Gavin Blackburn; Gareth D. Westrop; James Cotton; Matthew Berriman; Mandy Sanders; Suman Rijal; Graham H. Coombs; Jean-Claude Dujardin; Katharine C. Carter

doi:https://doi.org/10.1128/aac.00904-19

doi.org/10.1128/aac.00904-19

Genomic and Metabolomic Polymorphism among Experimentally Selected Paromomycin-Resistant Leishmania donovani Strains

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..., Katharine C. Carter

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Antimicrobial Agents and Chemotherapy4.90

Volume: 64, Issue: 1

Published: Dec 20, 2019

Abstract

Understanding the mechanism(s) underpinning drug resistance could lead to novel treatments to reverse the increased tolerance of a pathogen. In this study, paromomycin (PMM) resistance (PMM r ) was induced in three Nepalese clinical strains of Leishmania donovani with different inherent susceptibilities to antimony (Sb) drugs by stepwise exposure of promastigotes to...

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Title

Genomic and Metabolomic Polymorphism among Experimentally Selected Paromomycin-Resistant Leishmania donovani Strains

DOI

doi.org/10.1128/aac.00904-19

Published Date

Dec 20, 2019

Journal

Antimicrobial Agents and Chemotherapy

Volume

64

Issue

1

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