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Katharine C. Carter
Strathclyde Institute of Pharmacy and Biomedical Sciences
ImmunologyVisceral leishmaniasisSodium stibogluconateLeishmania donovaniBiology
66Publications
23H-index
1,365Citations
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Publications 64
Newest
#1Mohammad A. Obeid (YU: Yarmouk University)H-Index: 4
#2Teeranun Teeravatcharoenchai (Strathclyde Institute of Pharmacy and Biomedical Sciences)
Last. Valerie A. Ferro (Strathclyde Institute of Pharmacy and Biomedical Sciences)H-Index: 22
view all 7 authors...
Niosome nanoparticles can be prepared using different methods, each of which can affect the size and homogeneity of the prepared particles. The aim of this study was to establish if the method of p...
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#1C. D. Shaw (Strathclyde Institute of Pharmacy and Biomedical Sciences)H-Index: 2
#2Hideo ImamuraH-Index: 2
Last. Katharine C. Carter (Strathclyde Institute of Pharmacy and Biomedical Sciences)H-Index: 23
view all 12 authors...
Understanding the mechanism(s) underpinning drug resistance could lead to novel treatments to reverse the increased tolerance of a pathogen. In this study paromomycin (PMM) resistance (PMM-R) was induced in three Nepalese clinical strains of L. donovani, with different inherent susceptibility to antimony drugs (Sb), by step-wise exposure of promastigotes to PMM. Exposure to PMM resulted in the production of mixed populations of parasites even though a single cloned population was used at the sta...
2 CitationsSource
#1Emma McFarlane (Strathclyde Institute of Pharmacy and Biomedical Sciences)H-Index: 8
#2Thabang Mokgethi (Strathclyde Institute of Pharmacy and Biomedical Sciences)H-Index: 2
Last. Katharine C. Carter (Strathclyde Institute of Pharmacy and Biomedical Sciences)H-Index: 23
view all 7 authors...
Previous studies infecting global IL-4R-/-, IL-4-/- and IL-13-/- mice on a BALB/c background with the visceralising parasite Leishmania donovani have shown that the T helper 2 cytokines, IL-4 and IL-13, play influential but not completely overlapping roles in controlling primary infection. Subsequently, using macrophage/neutrophil-specific IL-4R deficient BALB/c mice, we demonstrated that macrophage/neutrophil unresponsiveness to IL-4 and IL-13 did not have a detrimental effect during L. donov...
3 CitationsSource
#1Lerato Hlaka (South African Medical Research Council)H-Index: 4
#2Michael-Jon Rosslee (South African Medical Research Council)H-Index: 2
Last. Reto Guler (South African Medical Research Council)H-Index: 24
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The slow development of major advances in drug discovery for the treatment of Mycobacterium tuberculosis (Mtb) infection have led to a compelling need for evaluation of more effective drug therapies against tuberculosis. New classes of drugs are constantly being evaluated for anti-mycobacterial activity with currently a very limited number of new drugs approved for TB treatment. Minor Groove Binders (MGBs) have previously revealed promising anti-microbial activity against various infectious agen...
4 CitationsSource
#1Katharine C. Carter (Strathclyde Institute of Pharmacy and Biomedical Sciences)H-Index: 23
#2Alexander B. Mullen (Strathclyde Institute of Pharmacy and Biomedical Sciences)H-Index: 21
In this review the benefits of using a drug delivery system (DDS) to improve therapeutic outcome will be discussed, using treatment of visceral leishmaniasis with amphotericin B (AMB), a poorly water soluble drug, as an exemplar. Progress in producing AMB formulations that can be given by intravenous, oral and pulmonary routes of administration is discussed.
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#1Fraser J. Scott (University of Strathclyde)H-Index: 7
#2Mireia Puig-Sellart (Strathclyde Institute of Pharmacy and Biomedical Sciences)H-Index: 1
Last. Colin J. Suckling (University of Strathclyde)H-Index: 26
view all 9 authors...
A series of 47 structurally diverse MGBs, derived from the natural product distamycin, was evaluated for anti-lung cancer activity by screening against the melanoma cancer cell line B16-F10. Five compounds have been found to possess significant activity, more so than a standard therapy, Gemcitabine. Moreover, one compound has been found to have an activity around 70-fold that of Gemcitabine and has a favourable selectivity index of greater than 125. Furthermore, initial studies have revealed thi...
4 CitationsSource
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#1Katharine C. Carter (Strathclyde Institute of Pharmacy and Biomedical Sciences)H-Index: 23
#2Mireia Puig (Strathclyde Institute of Pharmacy and Biomedical Sciences)H-Index: 1
Treatment by the pulmonary route can be used for administration of drugs that act locally in the lungs (e.g. treatment of lung cancer, chronic obstructive pulmonary disease, asthma) or non-invasive administration of drugs that act systemically. The potential of drug delivery systems formed from non-ionic surfactants or natural products i.e. proteins and polysaccharides for pulmonary delivery are discussed.
3 CitationsSource
#1Weam Siheri (Strathclyde Institute of Pharmacy and Biomedical Sciences)H-Index: 5
#2Tong Zhang (Glas.: University of Glasgow)H-Index: 16
Last. David G. Watson (Strathclyde Institute of Pharmacy and Biomedical Sciences)H-Index: 41
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Extracts from twelve samples of propolis collected from different regions of Libya were tested for their activity against Trypanosoma brucei, Leishmania donovani, Plasmodium falciparum, Crithidia fasciculata and Mycobacterium marinum and the cytotoxicity of the extracts was tested against mammalian cells. All the extracts were active to some degree against all of the protozoa and the mycobacterium, exhibiting a range of EC50 values between 1.65 and 53.6 μg/ml. The toxicity against mammalian cell...
14 CitationsSource
#1C. D. Shaw (Strathclyde Institute of Pharmacy and Biomedical Sciences)H-Index: 2
#2Julien Lonchamp (Strathclyde Institute of Pharmacy and Biomedical Sciences)H-Index: 5
Last. Katharine C. Carter (Strathclyde Institute of Pharmacy and Biomedical Sciences)H-Index: 23
view all 14 authors...
n this study, we followed the genomic, lipidomic and metabolomic changes associated with the selection of miltefosine (MIL) resistance in two clinically derived Leishmania donovani strains with different inherent resistance to antimonial drugs (antimony sensitive strain Sb-S; and antimony resistant Sb-R). MIL-R was easily induced in both strains using the promastigote-stage, but a significant increase in MIL-R in the intracellular amastigote compared to the corresponding wild-type did not occur ...
27 CitationsSource
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