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Antimicrobial Agents and Chemotherapy
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#1Yumei Niu (Sichuan University)H-Index: 2
#2Kun Wang (Sichuan University)H-Index: 2
Last. L. Zhang (Sichuan University)H-Index: 10
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Dental caries is the most common disease in the human mouth. Streptococcus mutans is the primary cariogenic bacteria. Propolis is a nontoxic natural product with a strong inhibitory effect on oral cariogenic bacteria. The polyphenol-rich extract from propolis inhibit S. mutans growth and biofilm formation, as well as the genes involved in virulence and adherence, through the inhibition of glucosyltransferases. However, because the chemical composition of propolis is highly variable and complex, ...
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#1Julia A. Loos (Facultad de Ciencias Exactas y Naturales)H-Index: 3
#2Valeria Dávila (Facultad de Ciencias Exactas y Naturales)H-Index: 1
Last. Andrea C. Cumino (Facultad de Ciencias Exactas y Naturales)H-Index: 9
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Alveolar echinococcosis (AE) is a severe disease caused by the larval stage of the tapeworm Echinococcus multilocularis Current chemotherapeutic treatment options based on benzimidazoles are of limited effectiveness, which underlines the need to find new anti-echinococcosis drugs. Metformin is an anti-hyperglycemic and anti-proliferative agent that shows activity against the related parasite E. granulosus Hence, we assessed the in vitro and in vivo effects of the drug on E. multilocularis Meform...
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#1Keira A. Cohen (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 9
#2Katharine E. Stott (University of Liverpool)H-Index: 6
Last. Alexander S. PymH-Index: 30
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In 2019, the WHO tuberculosis (TB) treatment guidelines were updated to recommend only limited use of streptomycin, in favor of newer agents or amikacin as the preferred aminoglycoside for drug-resistant Mycobacterium tuberculosis However, the emergence of resistance to newer drugs, such as bedaquiline, has prompted a reanalysis of antitubercular drugs in search of untapped potential. Using 211 clinical isolates of M. tuberculosis from South Africa, we performed phenotypic drug susceptibility te...
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#1Cynthia T. Nguyen (U of C: University of Chicago)H-Index: 5
#2Cindy Bethel (U of C: University of Chicago)H-Index: 9
Last. Angella Charnot-Katsikas (U of C: University of Chicago)H-Index: 8
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Different linezolid antimicrobial susceptibility testing (AST) methodologies yield varying results. In 2018, we transitioned our linezolid AST methodology from the Etest to Vitek 2. We sought to evaluate the impact of this change on antibiotic use among 181 inpatients with VRE infections. The transition from Etest to Vitek 2, resulted in an increase in linezolid susceptibility (38% versus 96%, p<0.001) and a reduction in time to active antibiotic therapy (3 versus 2.6 days, p=0.007).
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#1Joseph D. Lutgring (CDC: Centers for Disease Control and Prevention)H-Index: 5
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The treatment of infections caused by carbapenem-resistant Enterobacterales, especially New Delhi metallo-β-lactamase (NDM)-producing bacteria, is challenging. Although less common in the United States than some other carbapenemase-producers, NDM-producing bacteria are a public health threat due to the limited treatment options available. Here we report on the antibiotic susceptibility of 275 contemporary NDM-producing Enterobacterales collected from 30 U.S. states through the Centers for Diseas...
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#1Paulo Durão (IGC: Instituto Gulbenkian de Ciência)H-Index: 13
#2Ricardo S. Ramiro (IGC: Instituto Gulbenkian de Ciência)H-Index: 8
Last. Isabel Gordo (IGC: Instituto Gulbenkian de Ciência)H-Index: 28
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Most microbes live in spatially confined sub-populations. Under spatial structure, the efficacy of natural selection is often reduced (relative to homogeneous conditions), due to the increased importance of genetic drift and local competition. Additionally, under spatial structure, the fittest genotype may not always be the one with better access to the heterogeneous distribution of nutrients. The effect of radial expansion may be particularly relevant for the elimination of antibiotic resistanc...
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#1Paola Sandra Mercuri (University of Liège)H-Index: 14
#2Roberto Esposito (University of Liège)
Last. Moreno Galleni (University of Liège)H-Index: 41
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An analysis of the genome sequence of Yersinia mollaretii ATCC 43969 identified the blaYEM gene encoding YEM-1, a putative subclass B2 metallo-β-lactamase. The objectives of our work were to produce, purify and complete the kinetic characterization of YEM-1. YEM-1 displayed the narrowest substrate range among known subclass B2 metallo-β-lactamases since it can hydrolyze imipenem but not other carbapenems, such as biapenem, meropenem, doripenem and ertapenem, with a high catalytic efficiency. A p...
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#1Jennifer Martynowicz (IU: Indiana University)H-Index: 1
#2J. Stone DoggettH-Index: 9
Last. William Sullivan (IU: Indiana University)H-Index: 52
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Toxoplasma gondii, an obligate intracellular parasite that can cause life-threatening acute disease, differentiates into a quiescent cyst stage to establish lifelong chronic infections in animal hosts, including humans. This tissue cyst reservoir, which can reactivate into an acute infection, is currently refractory to clinically available therapeutics. Recently, we and others have discovered drugs capable of significantly reducing brain cyst burden in latently infected mice, but not to undetect...
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#1Teresa L. Parsons (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 16
#2Kevin N Gwenden (JHUSOM: Johns Hopkins University School of Medicine)
Last. Mark A. Marzinke (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 21
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Tenofovir (TFV) alafenamide fumarate (TAF) is an antiretroviral that has been evaluated in alternative drug delivery systems in several species. The ex vivo stability of TAF was evaluated. TAF was stable in dog, sheep, and macaque-spiked plasma. A negative bias was observed in TAF recovery in rabbit-spiked plasma; there was complete loss of TAF and corresponding over-estimation of TFV in rodent-spiked plasma. These data highlight considerations when evaluating TAF and TFV concentrations in pre-c...
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#1Hessel van der Weide (Erasmus University Medical Center)H-Index: 1
#2Unai CossíoH-Index: 4
Last. Gert Storm (UU: Utrecht University)H-Index: 79
view all 16 authors...
Antimicrobial peptides (AMPs) have seen limited clinical use as antimicrobial agents, largely due to issues relating to toxicity, short biological half-life, and lack of efficacy against Gram-negative bacteria. However, the development of novel AMP-nanomedicines, i.e. AMPs entrapped in nanoparticles, has the potential to ameliorate these clinical problems. The authors investigated two novel nanomedicines based on AA139, an AMP currently in development for the treatment of multidrug-resistant Gra...
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