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What remains after transient global amnesia (TGA)? An ultra-high field 7 T magnetic resonance imaging study of the hippocampus

Published on Feb 1, 2020in European Journal of Neurology4.387
· DOI :10.1111/ene.14099
Daniel Paech13
Estimated H-index: 13
(DKFZ: German Cancer Research Center),
Tristan Anselm Kuder13
Estimated H-index: 13
(DKFZ: German Cancer Research Center)
+ 7 AuthorsKristina Szabo25
Estimated H-index: 25
(Heidelberg University)
Abstract
  • References (9)
  • Citations (0)
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References9
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#1Xiaochuan Wang (Hangzhou Normal University)H-Index: 3
#2Ran Zhang (Ha Tai: Xiamen University)H-Index: 1
Last. Jiaxing Zhang (Ha Tai: Xiamen University)H-Index: 11
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BACKGROUND MRI signal diffusion-weighted imaging (DWI) hyperintensity in the hippocampus in patients with transient global amnesia (TGA) are resolved within several days after the onset of TGA. PURPOSE To use multiparametric MRI to unravel the sequelae of TGA. STUDY TYPE A prospective longitudinal study. POPULATION Eight TGA patients. FIELD STRENGTH/SEQUENCE A 3.0T Siemens Tim Trio MRI scanner with T1-weighted MPRAGE, diffusion-weighted echo planar imaging, and multiecho gradient-recalled echo s...
2 CitationsSource
#1Siegfried Trattnig (Medical University of Vienna)H-Index: 59
#2Elisabeth Springer (Medical University of Vienna)H-Index: 2
Last. Simon Robinson (Medical University of Vienna)H-Index: 24
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Abstract The growing interest in ultra-high field MRI, with more than 35.000 MR examinations already performed at 7 T, is related to improved clinical results with regard to morphological as well as functional and metabolic capabilities. Since the signal-to-noise ratio increases with the field strength of the MR scanner, the most evident application at 7 T is to gain higher spatial resolution in the brain compared to 3 T. Of specific clinical interest for neuro applications is the cerebral corte...
22 CitationsSource
#1Susanne J. van Veluw (UU: Utrecht University)H-Index: 18
#2Laura E M Wisse (UU: Utrecht University)H-Index: 5
Last. Geert Jan Biessels (UU: Utrecht University)H-Index: 51
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Hippocampal focal T2 hyperintensities (HT2Hs), also referred to as hippocampal sulcal cavities, are a common finding on Magnetic Resonance (MR) images. There is uncertainty about their etiology and clinical significance. In this study we aimed to describe these HT2Hs in more detail using high resolution 7 Tesla MR imaging, addressing 1) the MR signal characteristics of HT2Hs, 2) their occurrence frequency, 3) their location within the hippocampus, and 4) their relation with age. We also performe...
7 CitationsSource
#1Ingo UttnerH-Index: 18
#2S. WeberH-Index: 2
Last. R. HuberH-Index: 11
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Background: Hippocampal sulcal cavities (HSC) have been speculated to contribute to a higher vulnerability of memory pathways and might be a possible etiological factor in transient global amnesia (TGA). Therefore, we evaluated the influence of HSC on cognitive long-term outcome in TGA-patients. Methods: Fourteen otherwise healthy patients with the clinical syndrome of TGA in their history underwent a high-resolution magnetic resolution imaging and a comprehensive neuropsychological test battery...
7 CitationsSource
#1Jerome Joseph Maller (Monash University)H-Index: 33
#2Chantal Reglade-Meslin (ANU: Australian National University)H-Index: 10
Last. Paul B. Fitzgerald (Monash University)H-Index: 71
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Abstract While hippocampal volumes have been extensively examined in neuropsychiatric disorders and ageing, small areas of signal variation within the hippocampus commonly observed on MRI, described as hippocampal sulcal cavities (HSCs), have received less attention. We review the published literature on HSCs to examine their prevalence, putative aetiological factors such as hypertension, and possible cognitive correlates. HSCs were reported in 77% (66% weighted mean) of patients with memory dis...
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#1Doug GreveH-Index: 55
#2Bruce Fischl (MIT: Massachusetts Institute of Technology)H-Index: 95
Abstract The fine spatial scales of the structures in the human brain represent an enormous challenge to the successful integration of information from different images for both within- and between-subject analysis. While many algorithms to register image pairs from the same subject exist, visual inspection shows that their accuracy and robustness to be suspect, particularly when there are strong intensity gradients and/or only part of the brain is imaged. This paper introduces a new algorithm c...
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#1Thorsten BartschH-Index: 30
#2K. AlfkeH-Index: 19
Last. Günther DeuschlH-Index: 85
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The aetiology, pathomechanisms and anatomical correlates of transient global amnesia (TGA) still remain obscure. Recently, focal MR-signal diffusion-weighted imaging (DWI) changes in the hippocampus have been described in patients with TGA, but the exact localization, long term outcome and pathophysiological nature of these lesions still remain unknown. The topography and time course of hippocampal DWI lesions in 41 TGA patients was studied using serial 3 T high-resolution MR-imaging and correla...
129 CitationsSource
#1Tsutomu Nakada (Niigata University)H-Index: 26
#2Ingrid L. KweeH-Index: 26
Last. Robert T. Knight (University of California, Berkeley)H-Index: 90
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Objective: To investigate the fine structural integrity of the hippocampus in patients with transient global amnesia (TGA) using high-resolution T2 reversed (T2R) MRI. Methods: The authors performed detailed structural analysis of the hippocampus in 15 patients who had recovered from an episode of TGA and 150 randomly recruited normal volunteers across the adult age spectrum using high-resolution T2R MRI obtained on a 3.0-T system. An additional 100 subjects, with stroke or tumor, were similarly...
74 CitationsSource
#1Mark Jenkinson (John Radcliffe Hospital)H-Index: 67
#2Shubulade Smith (John Radcliffe Hospital)H-Index: 113
Last. Stephen J. Smith (John Radcliffe Hospital)H-Index: 140
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Registration is an important component of medical image analysis and for analysing large amounts of data it is desirable to have fully automatic registration methods. Many different automatic registration methods have been proposed to date, and almost all share a common mathematical framework — one of optimising a cost function. To date little attention has been focused on the optimisation method itself, even though the success of most registration methods hinges on the quality of this optimisat...
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