Gastric Mucosal Blood Flow and the Role of Proton Pump Inhibitors in Gastric Antral Vascular Ectasia (GAVE)

Purpose: GAVE is characterized endoscopically as radial hyperemic stria in the antrum and histologically as a proliferation of superficial capillaries and fibromuscular hyperplasia. The etiology is uncertain, but antral mucosal ischemia with reactive neovascularization has been proposed as a possible mechanism. The effect of proton pump inhibitors (PPI) on mucosal blood flow, a common form of therapy in GAVE patients, has not been investigated...