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A Cross-Sectional Study on the Dietary Pattern Impact on Cardiovascular Disease Biomarkers in Malaysia

Published on Dec 1, 2019in Scientific Reports4.01
· DOI :10.1038/s41598-019-49911-6
Tilakavati Karupaiah9
Estimated H-index: 9
(Taylors University),
Khun-Aik Chuah1
Estimated H-index: 1
(UKM: National University of Malaysia)
+ 4 AuthorsKalyana Sundram22
Estimated H-index: 22
Abstract
We conducted this cross-sectional population study with a healthy multi-ethnic urban population (n = 577) in Malaysia, combining nutritional assessments with cardiometabolic biomarkers defined by lipid, atherogenic lipoproteins, inflammation and insulin resistance. We found diametrically opposing associations of carbohydrate (246·6 ± 57·7 g, 54·3 ± 6·5%-TEI) and fat (total = 64·5 ± 19·8 g, 31·6 ± 5·5%-TEI; saturated fat = 14·1 ± 2·7%-TEI) intakes as regards waist circumference, HDL-C, blood pressure, glucose, insulin and HOMA2-IR as well as the large-LDL and large-HDL lipoprotein particles. Diets were then differentiated into either low fat (LF, 35% TEI or >70 g) and low carbohydrate (LC, 285 g) which yielded LFLC, LFHC, HFLC and HFHC groupings. Cardiometabolic biomarkers were not significantly different (P > 0.05) between LFLC and HFLC groups. LFLC had significantly higher large-LDL particle concentrations compared to HFHC. HOMA-IR2 was significantly higher with HFHC (1·91 ± 1·85, P  1.7 in the HFHC group was 2.43 (95% CI: 1·03, 5·72) times more compared to LFLC while odds of having large-LDL <450 nmol/L in the HFHC group was 1.91 (95% CI: 1·06, 3·44) more compared to latter group. Our data suggests that a HFHC dietary combination in Malaysian adults is associated with significant impact on lipoprotein particles and insulin resistance.
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References30
Newest
#1Dong D. Wang (Harvard University)H-Index: 19
#2Yanping Li (Harvard University)H-Index: 43
Last.Frank B. Hu (Harvard University)H-Index: 202
view all 8 authors...
#1Nor Aniza Abdullah (University of Newcastle)H-Index: 12
#2N.A. Abdul Murad (UKM: National University of Malaysia)H-Index: 1
Last.Rahman Jamal (UKM: National University of Malaysia)H-Index: 11
view all 12 authors...
#1Chee-Hee Se (UKM: National University of Malaysia)H-Index: 1
#2Ban-Hock Khor (UKM: National University of Malaysia)H-Index: 2
Last.Tilakavati KarupaiahH-Index: 9
view all 3 authors...
#1Zoë Harcombe (University of the West of Scotland)H-Index: 7
#2Julien S. Baker (University of the West of Scotland)H-Index: 21
Last.Fergal M. Grace (University of the West of Scotland)H-Index: 17
view all 7 authors...
#1Rahul Bahl (Royal Berkshire NHS Foundation Trust)H-Index: 1
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#2Marcus E. Kleber (Heidelberg University)H-Index: 47
Last.Hubert Scharnagl (Medical University of Graz)H-Index: 40
view all 10 authors...
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