Patients with pulmonary arterial hypertension with and without cardiovascular risk factors: Results from the AMBITION trial

BACKGROUNDThe purpose of this study was to compare patients with pulmonary arterial hypertension enrolled in the AMBITION trial with (excluded from the primary analysis set [ex-primary analysis set]) and without (primary analysis set) multiple risk factors for left ventricular diastolic dysfunction.METHODSTreatment-naive patients with pulmonary arterial hypertension were randomized to once-daily ambrisentan and tadalafil combination therapy,...