Journal of Heart and Lung Transplantation
Papers 19823
1 page of 1,983 pages (19.8k results)
#1Aini Xie (HUST: Huazhong University of Science and Technology)
#2Hui Yan (Houston Methodist Hospital)H-Index: 1
Last.Wenhao Chen (Cornell University)H-Index: 3
view all 7 authors...
ABSTRACT BACKGROUND Mammalian target of rapamycin (mTOR) inhibitors are valuable immunosuppressants in clinical transplantation, but mTOR regulation of allogeneic T cell responses is not fully understood. Here, we investigated the effects of T cell-specific mTOR deletion on allogeneic T cell responses and heart transplant survival. METHODS Wild type C57BL/6, Mtorfl/flCd4-Cre, Stat3fl/flCd4-Cre, and Mtorfl/flStat3fl/flCd4-Cre mice were transplanted with BALB/c heart allografts, with or without BA...
#1Indranee Rajapreyar (UAB: University of Alabama at Birmingham)H-Index: 4
#2J. Eduardo Rame (HUP: Hospital of the University of Pennsylvania)H-Index: 28
Last.Keshava Rajagopal (Memorial Hermann Texas Medical Center)H-Index: 18
view all 8 authors...
#1Sergio A. Acuna (U of T: University of Toronto)H-Index: 12
#2Nusrat Zaffar (U of T: University of Toronto)H-Index: 1
Last.Rohan D'Souza (U of T: University of Toronto)H-Index: 6
view all 5 authors...
Abstract Background Increasing numbers of women with thoracic transplants are planning and continuing pregnancies; however, pregnancy outcomes and risks to mother and baby have not been systematically assessed. Methods MEDLINE, EMBASE and Cochrane Central were searched from inception to January 2018 to identify studies reporting outcomes on three or more pregnancies following thoracic transplants. Pooled incidences were calculated using random-effect meta-analysis. Risk-of-bias was assessed usin...
#1Nicolas Adam (Paris V: Paris Descartes University)
#2G. Coutance (French Institute of Health and Medical Research)H-Index: 2
Last.Jean Paul Duong Van Huyen (University of Nantes)H-Index: 1
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ABSTRACT Background Molecular biology has emerged as a potential companion to histology for the diagnosis of rejection after heart transplantation. Reverse transcriptase multiplex ligation-dependent probe amplification (RT-MLPA) is a technique of targeted gene expression analysis suitable for formalin-fixed paraffin-embedded (FFPE) biopsies. Our aim was to assess RT-MLPA for the diagnosis of allograft rejection in heart transplantation. Methods We performed a cross-sectional, case-control, multi...
#1C. Spence ('QUB': Queen's University Belfast)
#2Bart M. Vanaudenaerde (Katholieke Universiteit Leuven)H-Index: 31
Last.Stijn E. Verleden (Katholieke Universiteit Leuven)H-Index: 25
view all 14 authors...
ABSTRACT Background Alterations in the lung microbiota may drive disease development and progression in patients with chronic respiratory diseases. Following lung transplantation (LTx), azithromycin is used to both treat and prevent chronic lung allograft dysfunction (CLAD). The objective of this study was to determine the association between azithromycin use, CLAD, acute rejection, airway inflammation and bacterial microbiota composition and structure after LTx. Methods Bronchoalveolar lavage (...
#1Samy M. Riad (UMN: University of Minnesota)H-Index: 4
#2U. Goswami (UMN: University of Minnesota)
Last.Arthur J. Matas (UMN: University of Minnesota)H-Index: 81
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Abstract Background Induction immunosuppression regimens for kidney transplant in lung transplant recipients vary widely. We studied the impact of induction types for kidney-after-lung transplant recipients. Methods Using the SRTR database between 1994 and 2015, we studied outcomes of patients and kidney grafts for 330 kidney-after-lung transplant recipients for whom induction before kidney transplant included depletional (n=115), non-depletional (n=170) or no induction (steroids only) (n=45). W...
#1Takahiro Hiraide (Keio: Keio University)H-Index: 2
#2Masaharu Kataoka (Keio: Keio University)H-Index: 18
Last.Keiichifukuda (Keio: Keio University)H-Index: 66
view all 22 authors...
Abstract Background A variant of c.14429G>A (p.Arg4810Lys, rs112735431) in the ring finger protein 213 gene (RNF213; NM_001256071.2) has been recently identified as a risk allele for pulmonary arterial hypertension (PAH). PAH can be added as a new member of RNF213-associated vascular diseases, which include Moyamoya disease and peripheral pulmonary stenosis. Our aim was to identify the clinical features and outcomes of PAH patients with this variant. Methods Whole-exome sequencing was performed ...
#1Jaime A. Hernandez-Montfort (Cleveland Clinic)
#2Rongbing Xie (UAB: University of Alabama at Birmingham)H-Index: 5
Last.Jennifer Cowger (HFHS: Henry Ford Health System)H-Index: 20
view all 12 authors...
Abstract Background Patients with advanced heart failure and cardiogenic shock (CS) often require temporary circulatory support (TCS) as a bridge to durable ventricular assist devices (dVAD). We aim to characterize longitudinal outcomes of patients with and without CS. Methods Between 2013 and 2017, 13,813 adult patients classified as Intermacs profiles 1-3 with CF-LVADs or BiVADs were registered into IMACS. Patients were sub-grouped according to support type (ECMO, IABP, other-TCS). Other-TCS i...
Abstract Background Antibody mediated rejection (AMR) is an important cause of lung allograft loss in some patients. Challenges with current diagnostic criteria limit timely detection. Ultrastructural studies (US) of endothelium allow early detection of AMR in kidney allografts. This study aimed to define the ultrastructural changes of the endothelium in lung allografts in the setting of AMR and determine its specificity for AMR. Methods US were performed on lung allograft biopsies of twelve pat...
Top fields of study
Intensive care medicine
Heart transplantation