Original paper

Structural Insight into Eukaryotic Sterol Transport through Niemann-Pick Type C Proteins

Cell45.50
Volume: 179, Issue: 2, Pages: 485 - 497.e18
Published: Oct 1, 2019
Abstract
Niemann-Pick type C (NPC) proteins are essential for sterol homeostasis, believed to drive sterol integration into the lysosomal membrane before redistribution to other cellular membranes. Here, using a combination of crystallography, cryo-electron microscopy, and biochemical and in vivo studies on the Saccharomyces cerevisiae NPC system (NCR1 and NPC2), we present a framework for sterol membrane integration. Sterols are transferred between...
Paper Details
Title
Structural Insight into Eukaryotic Sterol Transport through Niemann-Pick Type C Proteins
Published Date
Oct 1, 2019
Journal
Volume
179
Issue
2
Pages
485 - 497.e18
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