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#1Bernhard Hampoelz (MPG: Max Planck Society)
#2Andre Schwarz (Heidelberg University)
Last.Martin Beck (MPG: Max Planck Society)H-Index: 33
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Summary The molecular events that direct nuclear pore complex (NPC) assembly toward nuclear envelopes have been conceptualized in two pathways that occur during mitosis or interphase, respectively. In gametes and embryonic cells, NPCs also occur within stacked cytoplasmic membrane sheets, termed annulate lamellae (AL), which serve as NPC storage for early development. The mechanism of NPC biogenesis at cytoplasmic membranes remains unknown. Here, we show that during Drosophila oogenesis, Nucleop...
#1Hong-Viet V. Ngo (University of Tübingen)H-Index: 3
#2Jan Born (University of Tübingen)H-Index: 93
Slow oscillations and delta waves are neuronal activity rhythms that hallmark sleep, but until now their respective functional roles have been impossible to tease apart. Utilizing a closed-loop optogenetic approach in rats, Kim et al. (2019) dissociated the functions of these two canonical rhythms, showing they support the consolidation and forgetting of memories, respectively.
#1Rebecca L. Walker (UCLA: University of California, Los Angeles)H-Index: 1
#2Gokul Ramaswami (UCLA: University of California, Los Angeles)H-Index: 20
Last.Daniel H. GeschwindH-Index: 122
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Summary Tissue-specific regulatory regions harbor substantial genetic risk for disease. Because brain development is a critical epoch for neuropsychiatric disease susceptibility, we characterized the genetic control of the transcriptome in 201 mid-gestational human brains, identifying 7,962 expression quantitative trait loci (eQTL) and 4,635 spliceQTL (sQTL), including several thousand prenatal-specific regulatory regions. We show that significant genetic liability for neuropsychiatric disease l...
#1Dong-Wook Kim (California Institute of Technology)H-Index: 2
#2Zizhen Yao (Allen Institute for Brain Science)H-Index: 28
Last.Nico Pierson (California Institute of Technology)
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Summary The ventrolateral subdivision of the ventromedial hypothalamus (VMHvl) contains ∼4,000 neurons that project to multiple targets and control innate social behaviors including aggression and mounting. However, the number of cell types in VMHvl and their relationship to connectivity and behavioral function are unknown. We performed single-cell RNA sequencing using two independent platforms—SMART-seq (∼4,500 neurons) and 10x (∼78,000 neurons)—and investigated correspondence between transcrip...
#1Degang Wu (HUST: Huazhong University of Science and Technology)H-Index: 1
#2Jinzhuang Dou (Agency for Science, Technology and Research)H-Index: 1
Last.Chiea Chuen Khor (Agency for Science, Technology and Research)H-Index: 39
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Summary Underrepresentation of Asian genomes has hindered population and medical genetics research on Asians, leading to population disparities in precision medicine. By whole-genome sequencing of 4,810 Singapore Chinese, Malays, and Indians, we found 98.3 million SNPs and small insertions or deletions, over half of which are novel. Population structure analysis demonstrated great representation of Asian genetic diversity by three ethnicities in Singapore and revealed a Malay-related novel ances...
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