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Objective: Brain ischemia is the most common disease in the world caused by the disruption of the blood supply of brain tissue. Cell therapy is one of the new and effective strategies used for the prevention of brain damages. Sertoli cells (SCs) can hide from the host immune system and secrete trophic factors. So, these cells have attracted the attention of researchers as a therapeutic option for the treatment of neurodegenerative diseases. Also, memantine, as a reducer of glutamate and intracel...
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#1Zahra RezaeiH-Index: 1
#1Zahra Rezaei (University of Kashan)H-Index: 13
Last. Mehdi Totonchi (Royan Institute)H-Index: 15
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Objective: Health-related studies have been recently at the heart attention of the media. Social media, such as Twitter, has become a valuable online tool to describe the early detection of various adverse drug reactions (ADRs). Different medications have adverse effects on various cells and tissues, sometimes more than one cell population would be adversely affected. These types of side effect are occasionally associated with the direct or indirect influence of prescribed drugs but do not have ...
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#2Ali Neshasteh-RizH-Index: 3
Last. Hoormand MH-Index: 1
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Objective: Glioblastoma (GBM) is one of the devastating types of primary brain tumors with a negligible response to standard therapy. Repurposing drugs, such as disulfiram (DSF) and metformin (Met) have shown antitumor properties in different cell lines, including GBM. In the present study, we focused on the combinatory effect of Met and DSF-Cu on the induction of apoptosis in U87-MG cells exposed to 6-MV X-ray beams. Materials and Methods: In this experimental study, the MTT assay was performed...
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#1Zahra Shams Mofarahe (Shahid Beheshti University of Medical Sciences and Health Services)H-Index: 2
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Objective: Autograft transplantation of vitrified cortical ovarian tissue is an acceptable clinical technique for fertility preservation in women. Xenograft transplantation into animal models could be useful for evaluating the safety of human vitrified ovarian tissue. This study targeted to evaluate impact of vitrification on expression of the genes associated with folliculogenesis after xenograft transplantation of human vitrified ovarian tissue to gamma-irradiated mice. Materials and Methods: ...
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#1Atousa HaghiH-Index: 2
#2Mahdieh SalamiH-Index: 1
Last. Kianoosh MalekzadehH-Index: 6
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Objective: Acute myeloid leukemia (AML) is a clonal disorder of hemopoietic progenitor cells. The Raf serine/threonine (Ser/Thr) protein kinase isoforms including B-Raf and RAF1, are the upstream in the MAPK cascade that play essential functions in regulating cellular proliferation and survival. Activated autophagy-related genes have a dual role in both cell death and cell survival in cancer cells. The cytotoxic activities of arsenic trioxide (ATO) were widely assessed in many cancers. Sorafenib...
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Last. Keivan Zandi (Emory University)H-Index: 23
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Objective: Currently, application of oncolytic-virus in cancer treatment of clinical trials are growing. Oncolytic-reovirus is an attractive anti-cancer therapeutic agent for clinical testing. Many studies used mesenchymal stem cells (MSCs) as a carrier cell to enhance the delivery and quality of treatment with oncolytic-virotherapy. But, biosynthetic capacity and behavior of cells in response to viral infections are different. The infecting process of reoviruses takes from two-hours to one-week...
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#1Ying Wang (Hangzhou Normal University)H-Index: 1
#2Haibin WeiH-Index: 2
Last. Jiang Liu (Hangzhou Normal University)H-Index: 7
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Objective: We aimed to explore potential molecular mechanisms of clear cell renal cell carcinoma (ccRCC) and provide candidate target genes for ccRCC gene therapy. Materials and Methods: This is a bioinformatics-based study. Microarray datasets of GSE6344, GSE781 and GSE53000 were downloaded from Gene Expression Omnibus database. Using meta-analysis, differentially expressed genes (DEGs) were identified between ccRCC and normal samples, followed by Kyoto Encyclopedia of Genes and Genomes (KEGG) ...
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#1Xiu Wang (PRC: China Medical University (PRC))H-Index: 1
#1Xiaodong WangH-Index: 75
Last. Hongyu ChenH-Index: 1
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Objective: Endoplasmic reticulum (ER) stress causes an adaptive response initiated by protein kinase RNA-like ER kinase (PERK), Ire1 and ATF6. It has been reported that these upstream regulators induce microRNAs. The current study was designed to find a novel microRNA that mediates ER stress components and finally contributes to cell fate decision. Materials and Methods: In this experimental study, miR-706 levels were checked under different conditions of ER stress induced by Thapsigargin, Tunic...
1 CitationsSource
#1Ahmadi Badi S (IAU: Islamic Azad University)
Last. Seyed Davar SiadatH-Index: 14
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Objective: The gastrointestinal tract (GI) is colonized by a complex microbial community of gut microbiota. Bacteroides spp. have significant roles in gut microbiota and they host interactions by various mechanisms, including outer membrane vesicle (OMVs) production. In the present study, we extracted and assessed Bacteroides fragilis (B. fragilis) and Bacteroides thetaiotaomicron (B. thetaiotaomicron) OMVs in order to evaluate their possible utility for in vivo studies. Materials and Methods: I...
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#1Marjan OmidiH-Index: 5
Last. Seyed Mehdi KalantarH-Index: 8
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Objective: The aim of this study was to screen the potential of human embryos to develop into expanding blastocysts following in vitro embryo splitting and then assess the quality of the generated blastocysts based on chromosomal characteristics and using morphokinetics. Materials and Methods: In this experimental study, a total of 82 good quality cleavage-stage donated embryos (8- 14 cells) were used (24 embryos were cultured to the blastocyst stage as controls and 58 embryos underwent in vitro...
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