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Published on Nov 2, 2018in bioRxiv
Tim Stuart5
Estimated H-index: 5
Andrew Butler8
Estimated H-index: 8
+ 6 AuthorsRahul Satija33
Estimated H-index: 33
Single cell transcriptomics (scRNA-seq) has transformed our ability to discover and annotate cell types and states, but deep biological understanding requires more than a taxonomic listing of clusters. As new methods arise to measure distinct cellular modalities, including high-dimensional immunophenotypes, chromatin accessibility, and spatial positioning, a key analytical challenge is to integrate these datasets into a harmonized atlas that can be used to better understand cellular identity and...
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Published on Nov 24, 2018in bioRxiv
Sanne Boersma1
Estimated H-index: 1
(Utrecht University),
Deepak Khuperkar1
Estimated H-index: 1
(Utrecht University)
+ 4 AuthorsMarvin E. Tanenbaum19
Estimated H-index: 19
(Utrecht University)
mRNA translation is a key step in decoding genetic information. Genetic decoding is surprisingly heterogeneous, as multiple distinct polypeptides can be synthesized from a single mRNA sequence. To study translational heterogeneity, we developed the MoonTag, a new fluorescence labeling system to visualize translation of single mRNAs. When combined with the orthogonal SunTag system, the MoonTag enables dual readouts of translation, greatly expanding the possibilities to interrogate complex transla...
1 Citations Source Cite
Published on Jun 6, 2019in Cell 31.40
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Published on May 1, 2019in Cell 31.40
Ingmar B. Schäfer1
Estimated H-index: 1
Masami Yamashita3
Estimated H-index: 3
+ 4 AuthorsElena Conti46
Estimated H-index: 46
Summary The stability of eukaryotic mRNAs is dependent on a ribonucleoprotein (RNP) complex of poly(A)-binding proteins (PABPC1/Pab1) organized on the poly(A) tail. This poly(A) RNP not only protects mRNAs from premature degradation but also stimulates the Pan2-Pan3 deadenylase complex to catalyze the first step of poly(A) tail shortening. We reconstituted this process in vitro using recombinant proteins and show that Pan2-Pan3 associates with and degrades poly(A) RNPs containing two or more Pab...
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Published on May 22, 2019in Cell 31.40
K.M. Basore , A.S. Kim3
Estimated H-index: 3
+ 8 AuthorsJ. Smith
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