POT1 and Damage Response Malfunction Trigger Acquisition of Somatic Activating Mutations in the VEGF Pathway in Cardiac Angiosarcomas

Background Mutations in the POT 1 gene explain abnormally long telomeres and multiple tumors including cardiac angiosarcomas ( CAS ). However, the link between long telomeres and tumorigenesis is poorly understood. Methods and Results Here, we have studied the somatic landscape of 3 different angiosarcoma patients with mutations in the POT 1 gene to further investigate this tumorigenesis process. In addition, the genetic landscape of 7 CAS...