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Javier Benitez
Instituto de Salud Carlos III
572Publications
72H-index
23.3kCitations
Publications 572
Newest
Published on Jan 25, 2019in Nature Communications 11.88
Xia Jiang4
Estimated H-index: 4
(KI: Karolinska Institutet),
Hilary K. Finucane23
Estimated H-index: 23
(Broad Institute)
+ 330 AuthorsKaroline Kuchenbaecker3
Estimated H-index: 3
(UCL: University College London)
Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of European ancestry, here we estimate the pair-wise genetic correlations between breast, colorectal, head/neck, lung, ovary and prostate cancer, and between cancers and 38 other diseases. We observed statistically significant genetic cor...
Published in bioRxiv
Thomas U. Ahearn11
Estimated H-index: 11
(NIH: National Institutes of Health),
Haoyu Zhang2
Estimated H-index: 2
(Johns Hopkins University)
+ -3 AuthorsIrene L. Andrulis (Lunenfeld-Tanenbaum Research Institute)
Background: Genome-wide association studies have identified over 170 common breast cancer susceptibility loci, many of them with differential associations by estrogen receptor (ER). How these variants are related to other tumor features is unclear. Methods: Analyses included 106,571 invasive breast cancer cases and 95,762 controls of European ancestry with data on 178 genotyped or imputed single nucleotide polymorphisms (SNPs). We used two-stage polytomous logistic regression models to evaluate ...
Published on Jun 19, 2019in British Journal of Cancer 5.42
Frank Qian7
Estimated H-index: 7
(U of C: University of Chicago),
Matti A. Rookus44
Estimated H-index: 44
(NKI-AVL: Netherlands Cancer Institute)
+ 135 AuthorsMunaza Ahmed2
Estimated H-index: 2
(GOSH: Great Ormond Street Hospital)
Height and body mass index (BMI) are associated with higher ovarian cancer risk in the general population, but whether such associations exist among BRCA1/2 mutation carriers is unknown. We applied a Mendelian randomisation approach to examine height/BMI with ovarian cancer risk using the Consortium of Investigators for the Modifiers of BRCA1/2 (CIMBA) data set, comprising 14,676 BRCA1 and 7912 BRCA2 mutation carriers, with 2923 ovarian cancer cases. We created a height genetic score (height-GS)...
Published on Jul 1, 2019in Epidemiology 4.72
Louise C. Pyle10
Estimated H-index: 10
,
John Pluta25
Estimated H-index: 25
+ 27 AuthorsMark I. Geller76
Estimated H-index: 76
Published on Jun 27, 2019in Gastric Cancer 5.55
Javier Benitez72
Estimated H-index: 72
,
Roberta Marra + 1 AuthorsOriol Calvete3
Estimated H-index: 3
Background Type I gastric neuroendocrine tumors (gNETs) arise from hypergastrinemia in patients with autoimmune chronic atrophic gastritis. According to the classical model, the gastric H+/K+ ATPase was the causative autoantigen recognized by CD4+ T cells in chronic autoimmune scenario that secretes IL-17 and correlates with parietal cell (PC) atrophy, which drives to gastric achlorhydria and increases the risk for gastric neoplasms. However, the mechanism by which the inflammatory response corr...
Published on Oct 1, 2018in International Journal of Epidemiology 7.34
D. Gareth Evans99
Estimated H-index: 99
,
Anthony Howell98
Estimated H-index: 98
Background: In addition to the established association between general obesity and breast cancer risk, central obesity and circulating fasting insulin and glucose have been linked to the development of this common malignancy. Findings from previous studies, however, have been inconsistent, and the nature of the associations is unclear. Methods: We conducted Mendelian randomization analyses to evaluate the association of breast cancer risk, using genetic instruments, with fasting insulin, fasting...
Published on May 1, 2019in Molecular Oncology 5.96
Juan Miguel Baquero1
Estimated H-index: 1
,
Carlos Benitez-Buelga4
Estimated H-index: 4
(KI: Karolinska Institutet)
+ 5 AuthorsAna Osorio42
Estimated H-index: 42
Published on Mar 1, 2019in British Journal of Cancer 5.42
Maria Escala-Garcia1
Estimated H-index: 1
(NKI-AVL: Netherlands Cancer Institute),
Qi Guo8
Estimated H-index: 8
(University of Cambridge)
+ 232 AuthorsQin Wang35
Estimated H-index: 35
(University of Cambridge)
Background: We examined the associations between germline variants and breast cancer mortality using a large meta-analysis of women of European ancestry. Methods: Meta-analyses included summary estimates based on Cox models of twelve datasets using ~10.4 million variants for 96,661 women with breast cancer and 7697 events (breast cancer-specific deaths). Oestrogen receptor (ER)-specific analyses were based on 64,171 ER-positive (4116) and 16,172 ER-negative (2125) patients. We evaluated the prob...
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