The ferroportin Q248H mutation protects from anemia, but not malaria or bacteremia
Abstract
Iron acquisition is critical for life. Ferroportin (FPN) exports iron from mature erythrocytes, and deletion of the Fpn gene results in hemolytic anemia and increased fatality in malaria-infected mice. The FPN Q248H mutation (glutamine to histidine at position 248) renders FPN partially resistant to hepcidin-induced degradation and was associated with protection from malaria in human studies of limited size. Using data from cohorts including...
Paper Details
Title
The ferroportin Q248H mutation protects from anemia, but not malaria or bacteremia
Published Date
Sep 6, 2019
Journal
Volume
5
Issue
9
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