Original paper
High-Throughput Single-Cell Sequencing with Linear Amplification
Abstract
Conventional methods for single-cell genome sequencing are limited with respect to uniformity and throughput. Here, we describe sci-L3, a single-cell sequencing method that combines combinatorial indexing (sci-) and linear (L) amplification. The sci-L3 method adopts a 3-level (3) indexing scheme that minimizes amplification biases while enabling exponential gains in throughput. We demonstrate the generalizability of sci-L3 with proof-of-concept...
Paper Details
Title
High-Throughput Single-Cell Sequencing with Linear Amplification
Published Date
Nov 1, 2019
Journal
Volume
76
Issue
4
Pages
676 - 690.e10
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Notes
History