De novo mutations in mitochondrial DNA of iPSCs produce immunogenic neoepitopes in mice and humans
Abstract
The utility of autologous induced pluripotent stem cell (iPSC) therapies for tissue regeneration depends on reliable production of immunologically silent functional iPSC derivatives. However, rejection of autologous iPSC-derived cells has been reported, although the mechanism underlying rejection is largely unknown. We hypothesized that de novo mutations in mitochondrial DNA (mtDNA), which has far less reliable repair mechanisms than chromosomal...
Paper Details
Title
De novo mutations in mitochondrial DNA of iPSCs produce immunogenic neoepitopes in mice and humans
Published Date
Aug 19, 2019
Journal
Volume
37
Issue
10
Pages
1137 - 1144
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