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New metabolites produced by Streptomyces badius isolated from Giraffa camelopardalis feces

Published on Dec 1, 2019in Magnetic Resonance in Chemistry1.731
路 DOI :10.1002/mrc.4934
Yu Mu7
Estimated H-index: 7
(NU: Northeastern University),
Xiuyang Yu (NU: Northeastern University)+ 6 AuthorsXueshi Huang8
Estimated H-index: 8
(NU: Northeastern University)
Abstract
  • References (20)
  • Citations (0)
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References20
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#1Abhijeet M. Sarkale (IITGN: Indian Institute of Technology Gandhinagar)H-Index: 1
#2Amit Kumar (IITGN: Indian Institute of Technology Gandhinagar)H-Index: 2
Last. Chandrakumar Appayee (IITGN: Indian Institute of Technology Gandhinagar)H-Index: 6
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(R)-Paraconyl alcohol is found to be a key intermediate for the syntheses of many 纬-butyrolactone autoregulators. The chiral auxiliary approach and enzymatic resolution are the two common strategies employed so far in the literature for the asymmetric synthesis of (R)-paraconyl alcohol. Herein, we report the first organocatalytic approach for the short asymmetric synthesis of (R)-paraconyl alcohol in four steps and by a single column purification. Asymmetric syntheses of IM-2, SCB2, and A-factor...
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#1Jian Ma (NU: Northeastern University)H-Index: 4
#2Bixuan Cao (NU: Northeastern University)H-Index: 1
Last. Xueshi Huang (NU: Northeastern University)H-Index: 8
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Abstract A new chromanone derivative, named violacin A (1), was isolated from the fermentation broth of Streptomyces violaceoruber as a potential anti-inflammatory compound. The structure of violacin A was established using comprehensive NMR spectroscopic data analysis together with UV, IR, and MS data. The anti-inflammatory effects and action mechanisms of violacin A were investigated in vitro. The results demonstrated that violacin A attenuated the production of NO, IL-1尾, IL-6, and TNF-伪 as w...
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#1Bin TangH-Index: 1
#2Xi DuH-Index: 1
Last. Hong-Jin LiuH-Index: 1
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AbstractTwo new cadinane-type sesquiterpenes, trichapargins A (1) and B (2), were isolated from cultures of the basidiomycete Trichaptum pargamenum. Their structures were elucidated on the basis of extensive spectroscopic methods. Trichapargin A showed weak activity to SW480 with an IC50 value of 24.8聽渭M.
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#1Hui Lei (NU: Northeastern University)H-Index: 4
#2Xiuping Lin (CAS: Chinese Academy of Sciences)H-Index: 17
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Abstract Twelve previously undescribed polyketide derivatives, heterocornols A-L, and seven known analogues were isolated from a culture of the fungus Pestalotiopsis heterocornis associated with sponge. Their structures were elucidated by a comprehensive spectroscopic data analysis and CD Cotton effects. These compounds were evaluated for cytotoxic and antibacterial activities in聽vitro. Among them, heterocornols A-C, F-H, methyl-(2-formyl-3-hydroxyphenyl)propanoate, agropyrenol, and vaccinol G e...
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#1Dan ZhengH-Index: 2
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Six new fusicoccane-type diterpenoids (2鈥7) were isolated from the fermentation broth of Streptomyces violascens, which was isolated from Ailuropoda melanoleuca (giant panda) feces. The structures of these new compounds were elucidated by a detailed spectroscopic data and X-ray crystallographic analysis. Compounds 5鈥7 demonstrated cytotoxicity against five human cancer cell lines, with IC50 values ranging from 3.5 卤 0.7 to 14.1 卤 0.8 渭M. Cell adhesion, migration, and invasion assays showed that ...
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#1Nan DingH-Index: 2
#2Yi JiangH-Index: 55
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From a fermentation broth of Streptomyces albolongus obtained from Elephas maximus feces, nine bafilomycins (1鈥9) and seven odoriferous sesquiterpenoids (10鈥16) were isolated. The structures of the new compounds, including three bafilomycins, 19-methoxybafilomycin C1 amide (1), 21-deoxybafilomycin A1 (2), and 21-deoxybafilomycin A2 (3), and two sesquiterpenoid degradation products, (1尾,4尾,4a尾,8a伪)-4,8a-dimethyloctahydronaphthalene-1,4a(2H)-diol (10) and (1尾,4尾,4a尾,7伪,8a伪)-4,8a-dimethyloctahydron...
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#1Jian-Hai Ding (SCUN/SCUEC: South Central University for Nationalities)H-Index: 2
#2Zheng-Hui Li (SCUN/SCUEC: South Central University for Nationalities)H-Index: 6
Last. Ji-Kai Liu (SCUN/SCUEC: South Central University for Nationalities)H-Index: 30
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Two new sesquiterpenoids, trefoliol B (1) and trefoliol C (2), together with known echinocidin A (3), were isolated from cultures of the basidiomycetes Tremella foliacea. The new structures were elucidated on the basis of extensive spectroscopic methods. At the same time, trefoliol B (1) and echinocidin A (3) were tested for their cytotoxicities against five human cancer cell lines and for their inhibitory activities against isozymes of 11尾-hydroxysteroid dehydrogenases (11尾-HSD). No compound sh...
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#1Yi JiangH-Index: 14
#2Li Han (PRC: China Medical University (PRC))H-Index: 4
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Microbial symbionts play important roles in food digestion and absorption, immunity, pathogens resistance, and health maintaining of their hosts by coevolution. To provide new sources for discovering new leader compounds of drugs, the diversity and bioactivities of cultivable actinobacteria from animal feces have been studied. 31 species of animal fecal samples were collected fromYunnanWildAnimalPark. The purified cultures of actinobacteria were isolated from these samples by using 5 media. The ...
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#1Chiaki Nakano (UTokyo: University of Tokyo)H-Index: 7
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Identification of the SGR6065 gene product as a sesquiterpene cyclase involved in (+)-epicubenol biosynthesis in Streptomyces griseus
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#1Guo-Zhu Wei (CAS: Chinese Academy of Sciences)H-Index: 2
#2Na Zhu (CAS: Chinese Academy of Sciences)H-Index: 1
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Strain W5 was isolated from stem of Trewia nudiflora L. and identified as a member of Streptomyces according to its 16S rDNA partial sequence. From extracts of fermentation medium of W5, a new 纬-butyrolactone (1), together with nine known compounds [2-methyl-2,5-bornandiol (2), dimeric dinactin (3), (R)-2-((2R,5S)-tetrahydro-5-(2-oxopropyl)furan-2-yl)propanoic acid (4), 2-(5-(2-acetoxypropyl)-tetrahydrofuran-2-yl)propanoic acid (5/6), (卤)-homononactic acid (7/8), (卤)-nonactic acid (9/10)] was is...
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