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Yu Mu
Northeastern University
FermentationOrganic chemistryChemistryBiochemistryBiology
27Publications
7H-index
142Citations
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Publications 30
Newest
#1Hao Su (NU: Northeastern University)H-Index: 2
#2Caijuan Hu (NU: Northeastern University)H-Index: 2
Last. Xueshi Huang (NU: Northeastern University)H-Index: 8
view all 8 authors...
In the process of investigating the antifungal structure-activity relationships (SAR) of borrelidin and discovering antifungal leads, a semisynthetic borrelidin analogue, BN-3b with antifungal activity against Candida albicans, was achieved. In this study, we found that oxidative damage induced by endogenous reactive oxygen species (ROS) plays an important role in the antifungal activity of BN-3b. Further investigation indicated that BN-3b stimulated ROS accumulation, increased malondialdehyde (...
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#1Qingyin Liu (NU: Northeastern University)
#2Yu Mu (NU: Northeastern University)H-Index: 7
Last. Xueshi Huang (NU: Northeastern University)H-Index: 8
view all 10 authors...
Abstract A concise total synthesis of an exceedingly potent anti-inflammatory agent violacin A as well as the preparation of thirty analogues of this lead from commercially available orcinol are described. Highlights of our synthetic efforts involve Friedel-Crafts acylation, the regioselective etherification and esterification of phenolic hydroxyl groups, and Baker-Venkatamaran rearrangement to form basic skeleton of violacin A. The deprotection reaction with Pd-catalytic was involved to avoid t...
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#1Wen Xu (NU: Northeastern University)
#2Lu Zhang (URI: University of Rhode Island)H-Index: 2
Last. Liya Li (NU: Northeastern University)H-Index: 6
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Four new barringtogenol C-type triterpenoid saponins, namely acerplatanosides A – D (1–4), along with 22 known compounds (5–26), were isolated from the stem bark of Norway maple (Acer platanoides). Their structures were elucidated on the basis of comprehensive spectroscopic analyses and chemical hydrolysis. This is the first report of triterpenoid saponins isolated from Norway maple. Compounds 1, 3, and 4 showed cytotoxicity against 4 human cancer cell lines with IC50 values ranging from 9.4 to ...
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#1Yu Mu (NU: Northeastern University)H-Index: 7
#2Xiuyang Yu (NU: Northeastern University)
Last. Xueshi Huang (NU: Northeastern University)H-Index: 8
view all 9 authors...
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#1Xiaoxiao Gao (NU: Northeastern University)H-Index: 2
#2Hongzhi Yao (NU: Northeastern University)
Last. Cheng-Lin Jiang (Yunnan University)H-Index: 31
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Abstract Spectinabilin (1), spectinabilin derivative (2), and a new analogue, 2-demethyl-spectinabilin (3) were isolated from the fermentation broth of a soil-borne Streptomyces spectabilis strain. The structure of the new compound was elucidated by a detailed spectroscopic data analysis including data from CD spectra. Spectinabilin (1) demonstrated cytotoxicity against five human cancer cell lines, with IC50 values ranging from 18.7 ± 3.1 to 34.6 ± 4.7 μM, while derivatives 2 and 3 showed weak ...
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#1Yuanyuan Li (NU: Northeastern University)H-Index: 4
#2Dongli Li (Wuyi University)
Last. Liya Li (NU: Northeastern University)H-Index: 6
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Reactive oxygen species and subsequent oxidative stress are reported to play important roles in chronic metabolic diseases. Plant-derived polyphenols, especially food-derived phenolics, have attracted a lot of attention due to their potential usage against oxidative stress-related diseases. The leaf of Psidium guajava (known as guava) is regarded as a good resource of polyphenols and its products are commercially available in Japan as functional foods against multiple chronic metabolism disorder...
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#1Jialin Xu (NU: Northeastern University)H-Index: 4
#2Tingting Liu (NU: Northeastern University)H-Index: 3
Last. Liya Li (NU: Northeastern University)H-Index: 6
view all 10 authors...
3 CitationsSource
#1Caijuan Hu (NU: Northeastern University)H-Index: 2
#2Hao Su (NU: Northeastern University)H-Index: 2
Last. Xueshi Huang (NU: Northeastern University)H-Index: 8
view all 10 authors...
Abstract Borrelidin, a nitrile containing 18-membered polyketide macrolide, display potent antifungal activity. In this study, a library of borrelidin derivatives were synthesized. Their structures were elucidated by detailed spectroscopic data analysis. The antifungal activity and cytotoxicity of these target compounds were evaluated by broth microdilution and 3-(4,5-dimethylthiazol-2-yl)-3,5-phenytetrazoliumromide (MTT) methods. Among forty-seven prepared analogues, compound 3b had the inhibit...
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#1Jian MaH-Index: 4
#2Bixuan CaoH-Index: 1
Last. Xueshi HuangH-Index: 5
view all 8 authors...
Six new metabolites, actinofuranones D-I (compounds 1–6), were isolated together with three known compounds—JBIR-108 (7), E-975 (8), and E-492 (9)—from a fermentation broth of Streptomyces gramineus derived from the lichen Leptogium trichophorum. The structures of the new compounds 1–6 were established using comprehensive NMR spectroscopic data analysis, as well as UV, IR, and MS data. The anti-inflammatory activity of these isolated compounds were evaluated by examining their ability to inhibit...
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#1Feifei Liu (NU: Northeastern University)H-Index: 3
#2Hang Ma (URI: University of Rhode Island)H-Index: 12
Last. Liya Li (NU: Northeastern University)H-Index: 6
view all 9 authors...
Published data suggest that dietary-derived phenolics exert beneficial effects against hyperglycemia-mediated diseases, such as diabetes, through inhibiting the formation of advanced glycation endproducts (AGEs) and carbohydrate hydrolyzing enzyme activities. In the course of our investigation on the edible berry, Eugenia jambolana (known as Jamun), 21 phenolics (1–21) were isolated and identified from its seeds. Among these, one compound (1) is new and eleven compounds (3, 6, 9–13, 17, and 19–2...
1 CitationsSource
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