doi.org/10.1016/j.lfs.2019.116773
Original paper

Klotho improves diabetic cardiomyopathy by suppressing the NLRP3 inflammasome pathway

..., Xingjun Lai
3
Life Sciences5.20
Volume: 234, Pages: 116773 - 116773
Published: Oct 1, 2019
Abstract
NLRP3 inflammasome activation is essential for the development and prognosis of diabetic cardiomyopathy (DCM). The anti-aging protein Klotho is suggested to modulate tissue inflammatory responses. The aim of the present study was to examine the protective effects of Klotho on DCM.A streptozotocin-induced diabetes mouse model was established to assess the effects of Klotho in vivo, which was administered for 12 weeks. The characteristics of type...
Paper Fields
Paper Details
Title
Klotho improves diabetic cardiomyopathy by suppressing the NLRP3 inflammasome pathway
DOI
doi.org/10.1016/j.lfs.2019.116773
Published Date
Oct 1, 2019
Journal
Life Sciences
Volume
234
Pages
116773 - 116773
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