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#1Rana Dhar (ZJU: Zhejiang University)
#2Lejun Zhang (ZJU: Zhejiang University)
Last.Huifang Tang (ZJU: Zhejiang University)H-Index: 11
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Abstract Aims Electroacupuncture (EAc) has a pulmonary protective effect during cardiopulmonary bypass (CPB), but its molecular mechanisms including inflammasome activation signaling pathways remains unclear. Materials and methods Male Sprague Dawley rats were divided into control, CPB + EAc and CPB groups. Lung injury model was developed by CPB treatment and EAc (2/100 Hz) was carried out before CPB in the CPB + EAc group. Lung tissues were collected at two time points (0.5 h; 2 h) to determine...
#2Mary J. Cismowski (OSU: Ohio State University)H-Index: 13
Last.Lynette K. RogersH-Index: 24
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Abstract Aims MicroRNAs (miRs) and their importance in development, normal physiology, and disease have become increasingly recognized. Our laboratory is interested in miR-29 and its effects on lung development. These studies set out to identify optimal conditions for the measurement of miR-29 in heparinized, biobanked samples and to compare isoform expression patterns. Materials and methods The efficiency of three distinct heparinases were tested using reverse transcriptase polymerase chain rea...
#1Qian Chen (WHU: Wuhan University)H-Index: 1
#2Yao Wang (WHU: Wuhan University)H-Index: 1
Last.Zuo-Jiong Gong (WHU: Wuhan University)H-Index: 19
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Abstract Aim The purpose of the present study was to elucidate the protective effect of histone deacetylase 6 inhibitor ACY1215 on autophagy pathway in acute liver failure (ALF). Main methods Lipopolysaccharide (LPS) and d -galactosamine (D-Gal) were used to induce ALF model in C57BL/6 mice. D-Gal and tumor necrosis factor alpha (TNF-α) were applied in L02 cell. Autophagy inhibitor 3-MA and ACY1215 were conducted to induce 3-MA group, ACY1215 group and ACY1215+3-MA group. Results ACY1215 improve...
#1Nasrin Hamidi (Ardabil University of Medical Sciences)
#2Abdollah Nozad (Ardabil University of Medical Sciences)
Last.Mohammad Amani (Ardabil University of Medical Sciences)
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Abstract Aims Glutamatergic dysfunction is posed as a main stage in neurodegenerative disorders such as Alzheimer's disease (AD). Glutamate-mediated excitotoxicity contributes to cognitive dysfunction and cell death in AD. Ceftriaxone (CFT), a well-known upregulator of GLT-1, selectively induces the expression of glutamate transporter-1 (GLT-1) in different brain regions and therefore can be posed as a potential candidate for elimination of glutamate-induced excitotoxicity which is an early prom...
#1Bei-Bei LiuH-Index: 1
#2Yong-Bo PengH-Index: 1
Last.Qing-Hua LiuH-Index: 10
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Abstract Aims This study focused on investigating whether NS8593 reverses airway smooth muscle (ASM) contraction and the underlying mechanism. Main methods ASM contraction in mouse tracheal rings and lung slices was measured. Currents mediated by voltage dependent Ca2+ channels (VDCCs) and ACH-activated channels were measured using the whole-cell patch-clamp technique in single tracheal smooth muscle cells (TSMCs). Intracellular Ca2+ level and cell length were measured using an LSM 700 laser con...
#1Jingjie Xiao (WHU: Wuhan University)
#2Rui Yang (Shihezi University)
Last.Ma Kt (Shihezi University)H-Index: 6
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Abstract Aims Adiponectin (APN) is a protein hormone secreted mainly by adipose tissue that exhibits biological functions such as anti-inflammatory, anti-atherosclerotic, anti-apoptotic, hearing-protective and microcirculation-regulating functions. In this study, we explored whether APN could attenuate damage caused by CoCl2-induced hypoxic conditions in smooth muscle cells (SMCs) of the spiral modiolar artery (SMA). Main methods We first cultured and identified primary SMCs of the SMA. Afterwar...
#1Abdo A. Elfiky (Cairo University)H-Index: 7
#2Alaa M. Ismail (Cairo University)H-Index: 1
Abstract Aim To work on Hepatitis C Virus (HCV), one of the major causes of liver cirrhosis and hepatocellular carcinoma, polymerase of genotype 4a that have no solved structures deposited in the protein data bank (PDB) yet. Understanding the dynamics and testing some novel inhibitors are also covered. Materials and methods Molecular Dynamics Simulation (MDS) is performed for a period of 1 μs on comparatively modeled then validated NS5b of subtype 4a. Following MDS analysis, molecular docking is...
#1Biljana Musicki (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 27
#2Uzoma A. Anele (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 8
Last.Arthur L. Burnett (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 65
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Abstract Aims Nitric oxide (NO) has a critical, but not well understood, influence in the physiology of the lower urinary tract. We evaluated the effect of NO/phosphodiesterase (PDE)5 signaling in voiding dysfunction in the sickle cell disease (SCD) mouse, characterized by low NO bioavailability. Main methods Adult SCD (Sickle) and wild-type (WT) male mice were treated daily with sodium nitrate (10 mM) or vehicle. After 18 days, blood was obtained for nitrite measurement, urethra was collected f...
#1Keywan MortezaeeH-Index: 10
#2Yaiza Potes (University of Oviedo)H-Index: 5
Last.Bagher Farhood (KAUMS: Kashan University of Medical Sciences)H-Index: 10
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Abstract Cancer is a disease of high complexity. Resistance to therapy is a major challenge in cancer targeted therapies. Overcoming this resistance requires a deep knowledge of the cellular interactions within tumor. Natural killer (NK) cells and cytotoxic T lymphocytes (CTLs) are the main anti-cancer immune cells, while T regulatory cells (Tregs) and cancer associated fibroblasts (CAFs) facilitate immune escape of cancer cells. Melatonin is a natural agent with anti-cancer functions that has a...
Abstract Aims In the cell, both transcriptional and translational processes are tightly regulated. Cancer is a multifactorial disease characterized by aberrant protein expression. Since epigenetic control mechanisms are also frequently disrupted during carcinogenesis, they have been the center of attention in cancer research within the past decades. EEF1 complex members, which are required for the elongation process in eukaryotes, have recently been implicated in carcinogenesis. This study aims ...
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