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Life Sciences
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Papers 30552
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Published in Life Sciences3.45
Mona Torabi (TMU: Tarbiat Modares University), Hossein Azizi9
Estimated H-index: 9
(TMU: Tarbiat Modares University)
+ -3 AuthorsAmeneh Rezayof27
Estimated H-index: 27
(UT: University of Tehran)
Abstract Tobacco smoking is recognized as a life-threatening risk factor worldwide. Initiation of smoking primarily occurs during adolescence which is a critical developmental phase characterized by specific neurobehavioral alterations. The effect of adolescent nicotine exposure on vulnerability to opioid addiction has not been previously addressed. Furthermore, lateral paragigantocellularis (LPGi) is a key modulator of opiate effects. In this study we investigated the effect of adolescent nicot...
Published in Life Sciences3.45
Paulina Kleniewska8
Estimated H-index: 8
(Medical University of Łódź),
Rafal Pawliczak15
Estimated H-index: 15
(Medical University of Łódź)
Abstract Bronchial asthma and obesity are common health problems. Obesity is already responsible for 300,000 deaths per year. Aims The aim of the present study was to assess whether apocynin, alpha lipoic acid and probiotic administration in combination with low-fat diet supplementation influences the levels of antioxidant enzymes in the pulmonary tissues of obese asthmatic mice. Main methods The study was performed on male C57/BL6 mice divided into 10 groups: (I) control; (II) asthma; (III) obe...
Published in Life Sciences3.45
Esther Oluwasola Aluko (UNIUYO: University of Uyo), Olumuyiwa Abiola Adejumobi2
Estimated H-index: 2
(UI: University of Ibadan),
Adesoji A. Fasanmade4
Estimated H-index: 4
(UI: University of Ibadan)
Abstract Aims Hypertension is a global disease that has been combating the world health for ages. Peristrophe roxburghiana (PR) is used in traditional medicine to treat hypertension and other ailments. The present study examined phytochemical constituents, antioxidant activities and GC–MS analysis of extracts of PR leaf and also evaluated their anti-hypertensive and anti-lipidemic effects in NG-nitro-L-arginine methyl ester (L-NAME) hypertensive rats. Methods Wistar rats were grouped into two gr...
Published in Life Sciences3.45
Zhifa Wang (Fourth Military Medical University), Yunya Wang4
Estimated H-index: 4
(Fourth Military Medical University)
+ -3 AuthorsChunhu Gu12
Estimated H-index: 12
(Fourth Military Medical University)
Abstract Aims Acute myocardial insulin resistance is an independent risk factor for patients who undergo cardiac surgery with cardiopulmonary bypass (CPB). However, the underlying mechanism of insulin resistance during CPB has not been fully investigated. Materials and methods To explore the role of myocardial insulin resistance on the cardiac function and its underlying mechanism, CPB operation and pharmacological intervention were applied in mini pigs, and myocardial insulin signaling, glucose...
Published in Life Sciences3.45
Hu Li1
Estimated H-index: 1
(NAU: Nanjing Agricultural University),
Rahmani Mohammad Malyar (NAU: Nanjing Agricultural University)+ -3 AuthorsJinfeng Miao (NAU: Nanjing Agricultural University)
Abstract Aims The present study was to investigate the protective effects of Zn supplementation in OTA-induced apoptosis of Madin-Darby canine kidney (MDCK) epithelial cells and explore the potential mechanisms. Aiming to provides a new insight into the treatment strategy of OTA-induced nephrotoxicity by nutritional regulation. Main methods Initially, through MTT and LDH assay revealed that Zn supplementation significantly suppressed OTA-induced cytotoxicity in MDCK cells. Then, the production o...
Published in Life Sciences3.45
Lina Shan3
Estimated H-index: 3
,
Gang Zhang (Peking Union Medical College)+ -3 AuthorsXianbao Shi3
Estimated H-index: 3
Abstract Aim Licoricidin has multiple pharmacological activities. The present study was designed to investigate the permeability and pharmacokinetic behavior of licoricidin using in vitro models. Material and methods First, human liver microsomes and recombinant human supersomes were used to investigate the interactions between metabolic enzymes and licoricidin. In addition, rat, minipig, rabbit, dog, monkey, and human liver microsomes were used to determine metabolic differences among species. ...
Published in Life Sciences3.45
Liting Lan2
Estimated H-index: 2
,
Hua Wang1
Estimated H-index: 1
+ -3 AuthorsSuruibin12
Estimated H-index: 12
Abstract Aims The M3 muscarinic acetylcholine receptor (M3R) is a G protein-coupled receptor that is expressed in cases of non-small cell lung cancer (NSCLC). Previous studies demonstrated that M3R antagonists reduce the proliferation of NSCLC. However, how antagonists inhibit the NSCLC proliferation and migration is still little known. This study aims to investigate the mechanism of M3R involved in the growth of NSCLC. Main methods The CRISPR/Cas9 was used to knock out (KO) the M3R gene. A real...
Published in Life Sciences3.45
Xuelian Li2
Estimated H-index: 2
,
Zhiyang Li (Nanjing Medical University)+ -3 AuthorsXingjun Lai (NCU: Nanchang University)
Abstract Aims NLRP3 inflammasome activation is essential for the development and prognosis of diabetic cardiomyopathy (DCM). The anti-aging protein Klotho is suggested to modulate tissue inflammatory responses. The aim of the present study was to examine the protective effects of Klotho on DCM. Main methods A streptozotocin-induced diabetes mouse model was established to assess the effects of Klotho in vivo, which was administered for 12 weeks. The characteristics of type 1 DCM were evaluated by...
Published in Life Sciences3.45
Fei Li , Yangyang Zhang + -3 AuthorsQihai Gong18
Estimated H-index: 18
Abstract Aim This study aimed to investigate the effect of icariin (referred as ICA) on Alzheimer's disease (AD) model through endoplasmic reticulum (ER) stress pathway. Main methods Nine months male APP/PS1 and wild-type (WT) mice were randomly divided into four groups: APP/PS1 control, APP/PS1 + ICA, WT control and WT + ICA groups. The treated mice were given ICA 60 mg/kg/d and control mice were received the same volume distilled water for consecutive 3 months. The Morris water maze and Novel ...
Published in Life Sciences3.45
Xue Gong3
Estimated H-index: 3
(CQMU: Chongqing Medical University),
Cheng Huang1
Estimated H-index: 1
(CQMU: Chongqing Medical University)
+ -3 AuthorsBing Xu2
Estimated H-index: 2
(CQMU: Chongqing Medical University)
Abstract Aims To clarify the role of the gut-brain axis in depression. Main methods We used the iTRAQ technique to identify differential proteins in the intestine of the rat model of chronic unpredictable mild stress (CUMS)-induced depression. Significant differential proteins were subjected to Gene Ontology (GO) functional annotations and KEGG pathway enrichment analysis. Key proteins were validated at the mRNA and protein levels. The levels of cytokines in the intestine, serum and hypothalamus...
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